This dataset supports the article entitled: MIG-6 Regulates HDAC1-Mediated Angiogenesis and Tumorigenesis in PTEN-Deficient Endometrioid Endometrial Cancer

Article Authors: Shamsun Nahar, Tae Hoon Kim, Jae-Wook Jeong. University of Missouri- Obstetrics, Gynecology, and Women’s Health.

ReadMe Author: Shamsun Nahar, University of Missouri ORCID ID:0000-0002-0159-5558


DESCRIPTION OF THE DATA
In this study Pgrcre/+ Ptenf/f Mig-6over female mice were generated by breeding Pgrcre/+Ptenf/f male with Mig-6over females. 
The total RNA from mouse uterus were isolated by QIAGEN RNeasy Mini Kit following the vendor's manual.
The library was prepared by University of Missouri Genomic Technology Coe Total RNA Library Preparation (rRNA depletion) service. 
The raw reads were initially filtered by removing low quality reads (average quality scores >50) and aligned to the mm39 genome and assembled using Star 2.7.9a.
Differentially expressed genes (DEGs) were identified by the exact negative binomial test in the EdgeR software. The file containing the normalized counts for each samples.


This work was supported by the National Cancer Institute of the National Institutes of Health under Award Number R01CA264944 (to J.W.J). 
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Dataset available under a CC BY 4.0 license

Key words - Endometrial cancer, MIG-6, PTEN, angiogenesis, HDAC inhibitor