Delayed impact of COVID-19 on diabetes

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Introduction: Active COVID-19 illness can worsen glycemic control and induce diabetes-related complications such as diabetic ketoacidosis (DKA) in patients with prediabetes and diabetes. There is a lack of available research and data for cases of delayed diabetic complications secondary to COVID-19. We report two cases of COVID- 19 induced worsening of diabetic disease with a delayed onset including DKA and deteriorating glycemic control. Case Presentation: Patient-A is a 28-year- old Hispanic male with a history of prediabetes controlled with diet and exercise. He was diagnosed with DKA approximately 10 weeks following his COVID-19 illness and recovery. At the time of the DKA diagnosis, his HbA1c was 11.6%. Prior to his COVID-19 illness, his HbA1c was 5.6%. Patient-B is a 63-year-old white male with type 2 diabetes. He was diagnosed with worsening peripheral neuropathic pain one month following COVID-19 illness. Prior to COVID-19, his HbA1c was 7.5% compared to 10.3% two months post COVID-19 illness. Discussion: It is well documented that an active COVID-19 illness can worsen diabetes. It is important to recognize that COVID-19’s effect on diabetes may appear or persist for several weeks after recovery. Monitoring glycemic parameters during the 12-week time frame after COVID-19 illness may help identify these delayed effects. Identification of delayed onset or impact of COVID-19 illness on diabetes can help restore glycemic control and reduce morbidity.

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