Genetics in practice : applications of quantitative genetics to environment and educational pursuits
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"The ability to elucidate quantitative trait architecture and introduce potentially beneficial traits makes introgression a useful tool. Unfortunately, due to the nature of inheritance there are certainly limitations to the usefulness of this approach for introducing quantitative traits to a recipient population. In this project we attempted to introduce genes associated with water consumption to strains with opposite consumption profiles. Our two strains were selected based on previously quantified differences in consumption. In our first study, we confirmed differences in consumption based on strain. We also observed a potential impact of maternal care on consumption--particularly in males. In the second study, we estimated the difference in consumption was due to a minimum of about 10-12 genes. Such a high number of genes with little information on architecture makes reliable phenotypic selection difficult. Ultimately, we determined the phenotype was lost in LB animals but about six genes were still segregating in HB animals. This indicates that this method may be effective for determining a limited number of high-impact genes after a short number of generations. To further resolve the architecture of the difference between these two strains it would likely be useful to continue backcrossing then produce a generation of HB intercrosses. These individuals would provide a higher resolution population for mapping work."--Page 142-143
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.