Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
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Abstract
The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) and octoxynol-40 (Oc-40). A design of experiment (DOE) with JMP software was performed to optimize the formulation to delineate the effects of drug-polymer interactions. In this study, the amount of polymers HCO and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, clarity/ appearance and cytotoxicity on human corneal and retinal cell lines. A specific blend of HCO and Oc-40 at a particular wt% ratio which produced highest desirability generated by JMP software. The optimized formulations were characterized with all standard and safe and potentially suitable for ocular eye drop for future study.
Table of Contents
Introduction -- Ocular anatomy & drug delivery -- Diabetic Macula Edema (DME) -- Micelle application for drug delivery -- Preparation and optimization of triamcinolone acetonide-loaded noanmicelles -- Preparation and optimization development of fluocinolone acetonide-loaded nanomicelles -- Application of mathematical engineering steepest ascent method to optimize topical ocular nanomicellar formulation -- Summary and recommendations -- Appendix
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Ph.D.