The effect of mGluR2 3 agonist, LY379268, and a mGluR4 positive allosteric modulator, VU0155041, on conditioned taste aversion
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[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Metabotropic glutamate (mGlu) receptors are known to mediate learning and memory. Although evidence indicates a role for mGlu receptors (e.g., mGlu5) in conditioned taste aversion (CTA), a complete understanding of the subtype-specific involvement of mGlu receptors in this associative learning task remains to be determined. The current study examined the effects of (1R,4R,5S,6R)-4-Amino-2- oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268), a selective group II mGlu receptor agonist, and cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid (VU0155041), a mGlu4 receptor selective positive allosteric modulator, on the acquisition of CTA using male Sprague-Dawley rats. It was found that systemic injections of LY379268 prior to the conditioning trial decreased the acquisition of CTA on later test trials, while injections of VU0155041 prior to the conditioning trial had no effect on the acquisition of CTA.
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