Mesocopic and geomorphic analysis assessment of cenozoic deformation in the northern Wind River Basin, central Wyoming
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[EMBARGOED UNTIL 12/01/2025] Pregnancy-associated glycoproteins (PAGs) are aspartic proteinases produced by trophoblasts at the fetal-maternal interface. The exact functions of PAGs are unknown. This experiment aims to elucidate PAG function via the ablation of select porcine PAGs in embryos. PAG null embryos were generated via cytidine deaminase base editor. 2 guides targeting homology in 9 of the 12 PAGs were injected into zygotes via microinjection. Subsequent blastocysts were transferred to surrogates and then collected on various days of pregnancy (day 25, day 18). Day 25 yielded no pregnancies. On day 18, the conceptus was present, and PAGKO was confirmed. Histology showed aberrant vascular formation beneath the uterine epithelium. RNAseq analysis showed the down- regulation of several targets related to ECM remodeling. Porcine PAGs appear to affect proper ECM remodeling, though further research will be needed to elucidate the cellular mechanisms of these interactions.Within the northern Wind River Basin, just east of the Boysen Reservoir, the Stagner Creek Fault can be seen exposed within Quaternary gravel formations indicating that tectonic activity has occurred in the recent geologic history of the area. This is relative to the older tectonics of the region produced by Laramide age tectonism and responsible for the deeper tectonic structures such as the Shotgun Butte Thrust Fault. The local environment is sparsely populated. However, a threat to the dam of the Boysen reservoir as well as to the many oil and natural gas wells of the area exists which could have negative implications across the broader region. We used structure from motion (SFM) photography to develop DEMs and scarp profiles that show a 0.36m in the youngest surface that the fault cuts through and corresponds to a 6.3 magnitude quake. New and existing mesoscopic measurements show us that the region has experienced overall contraction. Schmidt hammer sampling helps confirm surface to age relationships in pre-Pinedale age surfaces but is not sensitive enough for post Pinedale age surfaces. The contraction explains the reverse sense of slip on the Stagner Creek Fault. From their relative positions, we also suggest that the Stagner Creek Fault at the surface and the Shotgun Butte Thrust at depth are most likely one in the same. This explains a reactivation of deeper, Laramide age structures
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M.S.