Which drugs work best for early Parkinson's disease?
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Levodopa/carbidopa is the most effective medical therapy for Parkinson's disease, but it's associated with dyskinesia (strength of recommendation [SOR]: A, Cochrane reviews and randomized controlled trials [RCTs]). Treating early Parkinson's disease with dopamine agonists such as bromocriptine can improve symptoms (SOR: B, Cochrane reviews, RCTs with heterogeneity).
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