Advancements in influenza glycobiology : impacts in influenza a virus evolution, fitness, and vaccine development
No Thumbnail Available
Authors
Meeting name
Sponsors
Date
Journal Title
Format
Thesis
Subject
Abstract
The Alphainfluenzavirus influenzae (FLUAV), is an enveloped, negative sense, single stranded RNA virus and part of the Orthomyxoviridae family. The FLUAV is comprised of eight genome segments, with segments HA and NA being the primary targets for host humoral responses and determining the subtypes of the influenza viruses. N-linked glycosylation may occur at the N-X-S/T sequon sites of NA and HA, and potentially impact the structure of HA and NA and thus transmissibility, antigenicity, and/or immunology of the FLUAV. FLUAVs circulating in humans have shown an increase of N-linked glycosylation sites, compared to those circulating in avian. Monitoring the heterogenicity and site occupancy of N-linked glycosylation is important in understanding the national history of FLUAVs. Advancements in glycomics technology and methods have helped precisely characterize N-linked glycosylation and develop therapeutic targets and broadly protective vaccines for influenza prevention and control.
Table of Contents
DOI
PubMed ID
Degree
M.S.