Comparison of sedated respiratory-gated computed tomography (CT) to anesthetized inspiratory : expiratory breath-hold CT in dogs
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[EMBARGOED UNTIL 08/01/2026] Dogs experiencing respiratory compromise typically have multiple respiratory disorders that can be underestimated or overlooked by thoracic radiography. The anesthetized, ventilator-assisted inspiratory: expiratory breath-hold (I:E BH) CT technique provides comprehensive evaluation of respiratory diseases of a diagnostic quality that is superior to images obtained without breath-holds. Sedated respiratory-gated (RG) CT has the potential to provide high-quality diagnostic images, avoid the potential risk of general anesthesia, and minimize motion artifact seen on sedated CT scans without respiratory gating. It was hypothesized that sedated RG-CT would generate images of comparable quality to anesthetized I:E-BH CT. Sedated RG-CT followed by I:E-BH CT images were prospectively acquired in fifty client-owned dogs with respiratory clinical signs. Thoracic CT scans from both techniques were assessed to 1) compare the presence or absence of the four major CT lung patterns and their sub-patterns, 2) provide a severity score for pulmonary parenchymal disease and a quantification score of the normal lung parenchyma, 3) identify bronchomalacia (defined as segmental and subsegmental airway collapse resulting in airflow limitation) and compare scoring between the scans. This study showed no significant difference between the two groups of images for the presence of the four major CT lung patterns and sub-patterns (p >0.05 for all), severity scores of parenchymal disease or normal lung, or the diagnosis of bronchomalacia.
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M.S.