The biopsychosocial factors impacting osteochondral allograft transplantation outcomes
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Osteoarthritis and focal cartilage defects of the knee can be a debilitating condition leading to poor quality of life, increased pain, and loss of joint function. These types of injuries are highly prevalent among young and active individuals, and treatment options that allow for a return to preoperative activity levels are limited. Osteochondral allograft transplantation has been shown to be highly effective as a treatment option for large fullthickness cartilage defects, and advances in this biological joint restoration technique continue to be made. OCAT outcomes have advanced significantly in the past decades due to improved graft storage and surgical techniques, but surgical revision rates remain higher than desired. To further optimize graft utilization, this dissertation examines the biopsychosocial factors impacting OCAT patient outcomes. It accomplishes this through two prospective registry-based clinical studies, and one finite element analysis of an OCAT knee. Osteochondral allografts are limited in availability and each graft is a highly valuable donation. All possible avenues of optimization should be explored to reach the highest utilization of graft tissue possible. This text explores the biopsychosocial factors impacting OCAT outcomes in the knee and is another step forward in the progression of this biological joint restoration procedure.
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Ph. D.