Regional mapping of the osteoarthritic joint
No Thumbnail Available
Authors
Meeting name
Sponsors
Date
Journal Title
Format
Thesis
Subject
Abstract
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI SYSTEM AT REQUEST OF AUTHOR.] Osteoarthritis (OA) progresses from a focal lesion of articular cartilage to whole-joint inflammation and degradation. The "focal spread" progresses in inhomogeneous patterns resulting in significant regional variation in production of biomarkers across the joint surface. This study was designed to map the production of specific biomarkers across the surface of an osteoarthritic joint. It was hypothesized that the regional production of these biomarkers would not strongly correlate to the histological grading of OA severity. ... Further study is required to confirm the findings of this study. Ongoing studies in our laboratory are aimed at further mapping the production of biomarkers across the surface of the OA joint; assessing the utility of inter- versus intra-patient mapping protocols to relate tissue biomarker production to development of symptomatic OA; and how patient-to-patient variability in ex vivo biomarker production relates to biomarker concentrations in synovial fluid, serum, and urine. The use of metabolic mapping of OA cartilage from patients as described in this study has the potential to provide novel insights into OA pathogenesis, pathobiology, and progression. The data from these studies may allow for identification of novel targets for treatment, as well as, biomarkers for the diagnosis, prognosis, diseases staging, and treatment monitoring in the OA clinical population.
Table of Contents
DOI
PubMed ID
Degree
M.S.
Thesis Department
Rights
Access to files is restricted to the campuses of the University of Missouri