Should you test for H pylori in patients with nonulcer dyspepsia?
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Helicobacter pylori in creases the risk of developing peptic ulcer disease (strength of recommendation [SOR]: B, cohort study), but there is no evidence that treating H pylori reduces that risk. Treating H pylori in patients with nonulcer dyspepsia reduces symptoms, but doesn't improve quality of life in the short term (SOR: B, systematic review of randomized controlled trials [RCTs] with inconsistent results), but may alleviate symptoms in the long term (SOR: B, RCT with methodological flaws). Eradicating H pylori is relatively inexpensive (SOR: A, systematic review of economic analyses).
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