Structural and kinetic studies of bifunctional and monofunctional proline catabolic enzymes
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PutAs, Proline dehydrogenase and P5C dehydrogenase are involved in the oxidation of proline to glutamate. Mutations in proline dehydrogenase and P5C dehydrogenase cause a disease condition known as hyperprolinemia. In this work I have solved the crystal structure of bifunctional PutA and P5C dehydrogenase. The structure of P5C dehydrogenase sheds light on the structural basis of hyperprolinemia. I have also used kinetic and thermodynamic methods to understand the molecular mechanism of hyperprolinemia.
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