Effect of corticosteroids on pain and function in knee osteoarthritis patients

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Clinical Inquiries question: Does the type of corticosteroid have an effect on pain and functional status of the knee in osteoarthritis (OA) patients receiving intra-articular injections? Evidence-based answer: In patients with knee OA, the type of injected steroid does not appear to alter pain and functional response, based on 3 head-to-head trials comparing intra-articular injection of different corticosteroid formulations for relief of knee pain and improvement of functional status (strength of recommendation A: based on small randomized controlled trials with consistent results).

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