What's the best test for HSV-2 after exposure?
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Enzyme-linked immunosorbent assay (ELISA ) tests based on herpes simplex virus 2's (HSV -2) glycoprotein G have demonstrated high sensitivity and specificity in determining seropositivity for HSV-2 antibodies (strength of recommendation [SOR]: C, based on cross-sectional studies). ELISA tests not based on glycoprotein G are also highly sensitive, but they are less specific for HSV-2 and are prone to false-positive results because of cross-reactivity with HSV -1 antibodies (SOR: C, based on cross-sectional studies).
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