New Clostridium difficile infection guidelines : Pearls for the hospitalist

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Clinical vignette: A 40 year-old female with no significant past medical history had a 3-day history of runny nose, headache, cough and post-nasal drip. Her physical exam showed erythematous pharyngeal wall but it was otherwise unremarkable. Her primary care provider prescribed amoxicillin-clavulanic acid for 7 days. She finished the antibiotic course, her symptoms gradually improved but she developed watery diarrhea up to 5 times per day. Her vital signs, blood cell counts, renal function and chemistries were normal. Her Clostridium difficile test returned positive. What treatment would you recommend for this patient?

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