Is combination pharmacotherapy effective for patients with acute depression?
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Use a combination of a presynaptic α2-autoreceptor antagonist (eg, mirtazapine or trazodone) and a monoamine reuptake inhibitor (eg, selective serotonin reuptake inhibitor [SSRI], serotonin-norepinephrine reuptake inhibitor [SNRI], or tricyclic antidepressant [TCA]) to treat acute depression in adult patients.
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