How effective is desmopressin for primary nocturnal enuresis?
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Desmopressin reduces the number of nights of primary noctural enuresis by at least 1 per week, and increases the likelihood of "cure" (defined as 14 consecutive dry nights) while treatment is continued (number needed to treat [NNT]=5-6) (strength of recommendation [SOR]: A, based on meta-analysis). Evidence suggests that the benefits of desmopressin are temporary, with a high relapse rate once treatment is discontinued (SOR: B). However, long-term therapy with occasional weaning attempts is a safe option (SOR: B). Evidence is inadequate to judge the relative efficacy of the nasal vs oral forms of desmopressin (SOR: C).
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