Is metformin effective for reducing weight in obese or overweight adolescents?
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Q: Is metformin effective for reducing weight in obese or overweight adolescents? Evidence based answer: Yes, to some degree—but it is of uncertain clinical significance. Over a period of 6 months, metformin modestly reduced weight (–2.1 kg) and body fat mass (–1.9%), but not body mass index (BMI) or lean body mass, in adolescents who were overweight or obese. This is comparable to lifestyle interventions (diet and exercise) supported with > 26 hours of counseling, which modestly improved BMI but not weight. (Strength of recommendation [SOR]: A, based on a large meta-analysis of randomized controlled trials [RCTs] of variable quality).
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