Rapid sarcomatous transformation of lung squamous cell carcinoma after neoadjuvant therapy: a case report
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Sarcomatoid carcinoma is a less common subtype of lung carcinoma (<1%). There is a mesenchymal-epithelial transition component and it carries grave prognosis. It is a subcomponent of Non-small cell lung cancers which is the leading cause of cancer mortality. Radiotherapy has previously been implicated as a etiologic agent resulting in this transformation. Here, we present a case which was initially diagnosed as squamous cell carcinoma on biopsy and a year later showed rapid progression and presented as high grade spindle cell predominant carcinoma with pleural, lymphovascular and perineural invasion, with a change in the staining pattern when compared to the previous biopsy after radiotherapy.
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