Technetium and rhenium Schiff base complexes for nuclear medicine
No Thumbnail Available
Authors
Meeting name
Sponsors
Date
Journal Title
Format
Thesis
Subject
Abstract
This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re(PR3)2(tmf2en)]+ were prepared by microwave assisted synthesis. A two-step (one-pot) procedure was utilized. In the first step, the Re(V) precursor (nBu4N)[ReOCl4] is reacted with the Schiff base ligand forming trans-[ReOCl(tmf2en) in situ. In the second step, a tertiary phosphine ligand is added yielding the reduced trans-[Re(PR3)2(tmf2en)][superscript +] species. The preparation of these trans-[Re(PR3)2(tmf2en)][superscript +] complexes by microwave assisted synthesis resulted in higher reaction yields and shorter reaction times compared to syntheses of similar Re(III) Schiff base complexes. The general methodology proved to be useful for the synthesis of mixed ligand Re(III) complexes with a diverse range of Schiff base ligands and phosphines.
Table of Contents
DOI
PubMed ID
Degree
Ph. D.
Thesis Department
Rights
OpenAccess.
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.