Relationship among body mass index, survival, and health-related quality of life among older patients with bladder cancer
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INTRODUCTION: The relationship between body composition and bladder cancer outcomes is complex. A higher Body Mass Index (BMI) seems to predispose to the development of bladder cancer, though the impact on survival is more convoluted. We sought to study this relationship in a cohort of older patients with bladder cancer and to examine the relationship between BMI and Health-related quality of life. METHODS: We included patients from the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey database, 1998 to 2021, with a diagnosis of bladder cancer. We assessed demographic characteristics, BMI, overall survival, and the Physical Component Summary(PCS) and Mental Component Summary(MCS) of the Short Form 36 Health Survey. We used ANOVA for univariate analysis and generalized linear models for multivariate analyses. Log-rank test was used to compare survival curves. RESULTS: The analysis found that BMI was predictive of overall survival, with improved survival for those who were overweight, obese, or severely obese when compared to those in the healthy range or underweight. PCS and MCS were correlated with BMI, with overweight patients demonstrating the highest scores These relationships remained statistically significant in multivariable analysis that accounted for other variables. CONCLUSIONS: We that the quality of life was highest among patients who were overweight (BMI 25-30) with severely obese patients having the worst quality of life. Increased BMI appears to offer a survival advantage among older patients with bladder cancer, while moderately elevated BMI offers a quality of life advantage as well.
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M.S.