Biomimetic reactions relevant to the study of abasic sites in DNA
No Thumbnail Available
Authors
Meeting name
Sponsors
Date
Journal Title
Format
Thesis
Subject
Abstract
Abasic (Ap) sites represent the most common form of DNA damage in mammalian cells. With steady state levels of 10,000 sites existing in each cell, there is a dire need to study these noxious biological electrophiles. While much work has been done to study these lesions using small biomolecules, such as oligonucleotides, there is still much to be learned regarding the fundamental organic chemistry. This thesis attempts to use the tools of basic organic chemistry to understand the complex reactions, structure, and equilibria of the abasic site.
Table of Contents
DOI
PubMed ID
Degree
Ph. D.
Thesis Department
Rights
OpenAccess.
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Copyright held by author.