The impact of cadmium and nickel on non-small cell lung cancer progression in vitro analysis of tumor progression

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Lung cancer ranks among the primary contributors to cancer-related fatalities globally, affecting both men and women (Zhai et al., 2019). Lung cancer begins when healthy cells in the lungs undergo genetic mutations that disrupt their normal growth and death cycle (Fong et al., 2008). These mutated cells divide uncontrollably, forming tumors and disrupting lung function. In 2015, lung cancer diagnoses affected 221,200 individuals in the United States, and this disease claimed the lives of another 158,040 individuals (Townsend et al., 2017). Annually, approximately 230,000 individuals in the United States receive a diagnosis of lung cancer, leading to an estimated 135,000 deaths per year. The mortality rate linked to lung cancer now surpasses the combined fatalities from prostate, breast, brain, and colorectal cancer.

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