The mMEDITATION study: a randomized controlled trial evaluating the effect of an mHealth meditation intervention compared to cardiovascular education on adults and older adults with anxiety and stress after myocardial infarction

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For adults and older adults with myocardial infarction, anxiety and stress are common sequelae after the event. Anxiety and stress can cause recurrent ischemia, arrhythmias, adverse cardiac events, lower quality of life, and higher mortality. This randomized controlled trial evaluated the effect of an 8-week mHealth meditation intervention compared to a cardiovascular education attention-control intervention on anxiety and stress in a convenience sample of adults and older adults with a non-ST elevation myocardial infarction or ST-elevation myocardial infarction. Engel’s biopsychosocial model, polyvagal theory, and the mindfulness stress buffering model provided the theoretical frameworks for this study. A conceptual model for mHealth meditation research in adults and older adults with myocardial infarction was developed to describe the interconnection of these theories. Study recruitment began on October 25, 2022 and ended on November 1, 2024. Sixty-four participants were included in the final analysis. Anxiety was measured with the state and trait subscales of the State-Trait Anxiety Inventory for Adults and stress was measured with the 10-item Perceived Stress Scale and salivary cortisol levels. Anxiety and stress were measured before and after the 8-week meditation intervention or cardiovascular education attention-control intervention. Between groups analysis revealed no statistically significant differences in delta values for anxiety scores on the State-Trait Anxiety Inventory for Adults (state subscale: p = .448; trait subscale: p = .495), stress scores on the 10-item Perceived Stress Scale (p = .168), or salivary cortisol levels (p = .112) between the meditation and attention-control groups. Limitations, including small sample size, homogenous participant population, inequalities in intervention dose, and factors impacting dependent variable measurement, should be considered when interpreting the results. This study makes a unique contribution to the body of knowledge about the effect of mHealth meditation on anxiety and stress in adults and older adults with myocardial infarction. Further theoretical development is needed to support the conceptual model for mHealth meditation research in adults and older adults with myocardial infarction. Future research might include multi-site, fully-powered, randomized controlled trials that evaluate the effect of mHealth meditation interventions on individuals with a variety of cardiac diagnoses.

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Introduction -- Review of literature -- Theoretical framework and methodology -- Results -- Discussion

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Ph.D. (Doctor of Philosophy)

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