Simulation model for drug distribution
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"OBJECTIVES: Association equilibrium calculations for drug-protein binding will lead to the knowledge of the free (unbound) concentration of the drug in the plasma. The free drug in the plasma is generally considered to be available for distribution of the drug to the tissue which is involved in the excretion of the drug (15). The objectives of this study were: 1. To develop appropriate equations to compute drug distribution for two drugs on binding sites on serum albumin with special emphasis on free drug concentrations. 2. To develop a computer program to carry out the computations, print tabular output and also to prepare Cal Comp plots for competetive displacement in teractions on serum albumin. 3. To develop appropriate equations to compute the effects of two drugs competing for an enzymatic site in the liver and the consequences of such inhibition on the excretion of a drug in the bile. 4. To develop a computer program to carry out the computations for competetive inhibition on the drug concentrations in the bile, print tabular output and prepare Cal Comp plots. 5. To compare the mathematical model and computer program with experimental data for two binary anticoagulant drugs system, Warfarin-Bromosulfophthalein (BSP) and Warfarin-Bilirubin."--Page 3.
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