Transient gestation-associated diabetes insipidus (GDI)
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Diabetes insipidus (DI) is a disorder characterized by polydipsia, polyuria, and the formation of hypotonic urine. DI can be broadly classified into central DI and nephrogenic DI. In summary, central DI is due to the defective synthesis or release of arginine-vasopressin (AVP) or anti-diuretic hormone (ADH) from the hypothalamo-pituitary axis. Nephrogenic DI is due to renal insensitivity to AVP. Transient pregnancy-associated or gestational-associated diabetes insipidus (GDI) is a rare condition that occurs during the third trimester affecting between 2 and 6 cases per 100,000 pregnancies ((1, 2, 3, 4). It is thought to occur due to elevated levels of the enzyme vasopressinase, which is released from the placenta and causes the degradation of ADH (5).
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.