Browsing by Thesis Department "Pharmaceutical Sciences (UMKC)"
Now showing items 41-60 of 76
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
(2021)PART I: SELF-ASSEMBLING TACROLIMUS NANOMICELLES FOR BACK OF THE EYE DISEASES Vrinda Gote, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2021 ABSTRACT Neovascular age-related ... -
Novel Approaches for Targeted Delivery of Cancer Therapeutics to Nuclei of Malignant Cells
(University of Missouri--Kansas City, 2016)The primary goal of this project is to increase specific uptake of anti-cancer therapeutics by nuclei of cancer cells. A lot of research has been done to target therapeutics specifically across plasma membrane of ... -
Novel Dichloroacetate Prodrugs for Improved Targeting of Breast Cancer Chemotherapeutics
(University of Missouri -- Kansas City, 2019)It is well documented that most cancer cells utilize aerobic glycolysis or Warburg metabolism instead of mitochondrial oxidative phosphorylation for cell energy production. Dichloroacetate is a synthetic small molecule ... -
Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
(University of Missouri -- Kansas City, 2019)Overall aim of this research project is to develop folic acid targeted nanomicelles loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye. Retinoblastoma and uveitis are diseases that ... -
Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)In this study different in vitro models were developed to study the long term and short term drug- drug interactions occurring upon oral administration. MDCK cells were stably transfected for the simultaneous expression ... -
Novel nanocarriers to improve drug delivery for age-related macular degeneration
(2021)Visual impairment affecting the posterior segment of the eye is a significant health problem causing a deterioration of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on ... -
Novel Prodrugs and Self-Assembling Nanocarriers to Improve Drug Delivery
(University of Missouri -- Kansas City, 2018)PART I: DIPEPTIDE PRODRUG APPROACH TO IMPROVE INTESTINAL ABSORPTION OF LOPINAVIR Lopinavir (LPV), a highly potent second-generation HIV-1 protease inhibitor, is currently indicated in HIV-1 infection. However, poor ... -
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ... -
Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers
(2015-06-19)Our primary aim was to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized. Low molecular weight diblock co-polymers, ... -
Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry
(2019)In Part I, the synthesis of chenodeoxychoic acid (CDCA) derivatives towards the construction of unique chemical architectures are reported. Building on previously described methods, CDCA based macrocycles with inner cavities ... -
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
(University of Missouri -- Kansas City, 2018)Prostate cancer is the most common male malignancy and remains the second-leading cause of death due to cancer in American men. While surgery and radiation are effective in prostate cancer therapy at early stages, the ... -
Preparation Of Oligonucleotide Delivery Agents And Insulin Depot Materials Using Solid Phase Synthesis
(2014)Short interfering RNA (siRNA) induced RNA interference (RNAi) is capable of preventing gene translation. In a laboratory setting, various transfection methods have enabled this mechanism to be used for routine gene silencing ... -
Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
(University of Missouri -- Kansas City, 2018)This study is divided into three specific aims. Specific aim #1 focused on synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and ethylene-glycol with varied molecular weights, (ii) ... -
Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
(2014)The main objective of this project is to develop prodrug strategies to circumvent efflux pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs), thereby enhancing oral and brain absorption ... -
Proinflammatory Cytokine / Chemokine Expression in Human Astrocytes: Induction by HIV-1 Nef
(2014)The mortality and morbidity of HIV-1 infected individuals were declined significantly by the introduction of highly active antiretroviral therapy (HAART). Nevertheless, different forms of HIV-associated neurocognitive ... -
Protein production and applications of NMR in pharmaceutical sciences
(2014-08-28)The objective of Part I (Protein production for structural elucidation using NMR) is to design and develop strategies of producing amyloid beta protein for structural analysis using NMR. Amyloid beta oligomers are considered ... -
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ... -
Refinement and Applications of Light Controlled Biological Processes
(University of Missouri–Kansas City, 2015)For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ... -
Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
(2014-08-28)Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic intracellular drug concentration, is one of the predominant factors limiting effective cancer chemotherapy. Several possible mechanisms and ... -
Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
(University of Missouri--Kansas City, 2012)Alcohol abuse is known to induce liver diseases and neurodegeneration. Chronic alcohol use during medication is known to decrease drug efficacy and increase toxicity. In addition, alcohol is known to interact with other ...