Browsing by Author/Contributor "Hannink, Mark, 1958-"

Now showing items 1-6 of 6

  • Characterization of PGAM5 

    Wilkins, Jordan, 1983- (University of Missouri--Columbia, 2013)
    Programmed cell death (PCD) is a naturally occurring event that is highly regulated and required for normal development. The protein phosphoglycerate mutase 5 (PGAM5) has been implicated in apoptosis, necrosis, and autophagy ...

  • Crystal structure of the kelch domain of human keap1 

    Li, Xuchu, 1976- (University of Missouri--Columbia, 2005)
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Nrf2-Keap1 signal transduction pathway senses oxidative stress and protects eukaryotic cells against oxidative damage and cancer. The transcription ...

  • Identifying substrate proteins for GAN1 and Keap1 

    Eberle, Carolyn E.; Hannink, Mark, 1958-; Sun, Zheng (University of Missouri--Columbia. Office of Undergraduate Research, 2004)
    GAN1 and Keap1 are proteins characterized by a N-terminal BTB domain and a C-terminal Kelch repeat domain. Both of these domains are protein-protein interaction domains, suggesting that these BTB-Kelch proteins form signaling ...

  • Regulation of Nrf2 by a keap1-dependent E3 ubiquitin ligase 

    Lo, Shih-Ching, 1979- (University of Missouri--Columbia, 2007)
    Oxidative damage to biological macromolecules has been implicated in diverse pathophysiological processes, including cancer, neurodegeneration, aging and cardiovascular disease. The Nrf2 transcription factor regulates ...

  • Sensitization of neuroblastoma to apoptosis mediated by oncogene-specific antisense peptide nucleic acid oligomers [abstract] 

    Berkhalter, Rebecca; Jia, Fang; Hannink, Mark, 1958-; Lewis, Michael R. (University of Missouri--Columbia. Office of Undergraduate Research, 2004)
    Apoptosis, or programmed cell death, is a major pathway by which chemotherapeutic drugs kill tumor cells. The B-cell lymphoma/leukemia-2 (bcl-2) and FLICE-inhibitory (FLIP) cellular oncogenes promote tumor cell survival, ...

  • Yeast two-hybrid screen of PGAM5 [abstract] 

    Unverferth, Julie; Lo, Shih-Ching, 1979-; Hannink, Mark, 1958- (University of Missouri--Columbia. Office of Undergraduate Research, 2007)
    PGAM5 is a member of the phosphoglycerate mutase family. It has been identified as a substrate for BTB-Kelch protein Keap1, a substrate adaptor for a cullin-based ubiquitin ligase. Keap1 plays an important role in cellular ...