Browsing by Author/Contributor "Hardin, Christopher D."
Now showing items 1-5 of 5
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Caveolin-1 A scaffold for microcompartmental organization of membrane-associated glycolysis
Hernandez, Mark J. (Mark Jerry), 1979- (University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The role of membrane caveolae in the compartmentation of membrane glycolytic metabolism indicates a pivotal role of caveolin in the localization of ... -
Lipotoxicity in smooth muscle
Mattern, Heather M., 1979- (University of Missouri--Columbia, 2006)Atherosclerosis and bladder dysfunction can both result from the high lipid levels that occur with obesity and diabetes and can cause cell dysfunction and death, termed lipotoxicity, in various cell types. However, ... -
Mutations to the caveolin scaffolding domain reduces Caveolin-1 targeting of glycolytic enzymes to lymphocyte membranes [abstract]
Fischer, Caitlin; Hernandez, Mark J. (Mark Jerry), 1979-; Hardin, Christopher D. (University of Missouri--Columbia. Office of Undergraduate Research, 2007)Previously, we found caveolin (CAV-1) expressed by transfection in cultured lymphocytes induced caveolae formation and targeted the glycolytic enzyme phosphofructokinase (PFK) to the membrane. We also found CAV-1 targets ... -
Overexpression of caveolin-1 results in increased plasma membrane trageting of phosphofructokinase: The structural basis for a membrane associated metabolic compartment
Raikar, Leena; Vallejo, Johana; Hardin, Christopher D. (University of Missouri--Columbia. Office of Undergraduate Research, 2004)Previous work from our laboratory has shown that glycolysis and gluconeogenesis occur in separate compartments within the vascular smooth muscle cell ( VSM ) and that their intermediates do not mix freely in the cytoplasm. ... -
Vascular smooth muscle metabolism and pyruvate dehydrogenase
Ward, Kathryn R., 1985- (University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In dyslipidemic states, most muscle types preferentially utilize fatty acids rather then glucose largely due to modulation of the pyruvate dehydrogenase ...