Browsing by Author/Contributor "Hoffman, Timothy Joseph, 1958-"
Now showing items 1-14 of 14
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99mTc-DPR-SSS-BBN for diagnosis of human cancers [abstract]
Heinzke, Laura; Retzloff, Lauren Brooke, 1980-; Lane, Stephanie R., 1982-; Prasanphanich, Adam; Sieckman, Gary; Rold, Tammy L.; Hoffman, Timothy Joseph, 1958-; Smith, Charles J. (Charles Jeffrey), 1969- (University of Missouri--Columbia. Office of Undergraduate Research, 2008)Receptor-specific, radiolabeled peptides have become increasingly popular as targeting vectors for the development of new diagnostic radiopharmaceuticals. The over-expression of certain receptors such as the gastrin releasing ... -
Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for 105Rh(III)
Carroll, Valerie (Valerie Nicole) (University of Missouri--Columbia, 2013)Rhodium-105 is an attractive nuclide for radiotherapeutic applications due to its nuclear properties (566 keV β-, 319 keV [19%], 306 keV [5%]) and the kinetic stability of Rhodium (III) complexes with soft sulfur donor ... -
Discrete NaI(TI) crystal detector optimization for small animal SPECT molecular imaging
Daibes Figueroa, Said, 1977- (University of Missouri--Columbia, 2005)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Dual-modality imaging instrumentation has allowed the noninvasive analysis of preclinical models of human disease. A combined microSPECT/CT unit (Siemens) ... -
Evaluation of a new series of copper-64-nota-bombesin targeted radiopharmecuticals with PET imaging potential [abstract]
Prasanphanich, Adam; Nanda, Prasant Kumar; Rold, Tammy L.; Hoffman, Timothy Joseph, 1958-; Smith, Charles J. (Charles Jeffrey), 1969- (University of Missouri--Columbia. Office of Undergraduate Research, 2007)Tissue-specific radiopharmaceuticals having promise as diagnostic and therapeutic targeting vectors for human cancers is of significant interest. In recent years, our group and many others have focused upon design and ... -
In vitro/in vivo assessment of novel 99mTc-bombesin conjugates in human cancer tissue [abstract]
Heinzke, Laura; Prasanphanich, Adam; Lane, Stephanie R., 1982-; Retzloff, Lauren Brooke, 1980-; Rold, Tammy L.; Sieckman, Gary; Hoffman, Timothy Joseph, 1958-; Smith, Charles J. (Charles Jeffrey), 1969- (University of Missouri--Columbia. Office of Undergraduate Research, 2007)Receptor-specific, radiolabeled peptides are becoming increasingly popular as targeting vectors for the development of new diagnostic radiopharmaceuticals. The over-expression of certain receptors such as the gastrin ... -
Investigating the bifunctional chelate approach for radiopharmaceutical development
Bottenus, Brienne N., 1984- (University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ... -
The magic bullet: Creating Indium-111 bombesin targeting vectors for use in diagnostic imaging of prostate and breast cancer [abstract]
Cook, Benjamin; Garrison, Jered C.; Bottenus, Brienne N., 1984-; Sieckman, Gary; Rold, Tammy L.; Shelton, Tiffani; Hoffman, Timothy Joseph, 1958- (University of Missouri--Columbia. Office of Undergraduate Research, 2007)Background: According to the American Cancer Society, over 68,000 men and women will die from prostate and breast cancer in this year alone. Prostate, breast and other cancers have been shown to express the BB2 receptor. ... -
Micro-imaging characterization of mouse models of metastasis
Winkelmann, Christopher Todd, 1971- (University of Missouri--Columbia, 2005)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Non-invasive imaging techniques have been recently developed to characterize animal models of disease. The overarching hypothesis of this work explores ... -
Overexpression of the RNA-binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis [abstract]
Gubin, Matthew M.; Calaluce, Robert; Davis, J. Wade; Magee, Joseph D.; Strouse, Connie S.; Shaw, Daniel P.; Hoffman, Timothy Joseph, 1958-; Rold, Tammy L. (2010)Breast cancer is the second most common cancer in women and causes the death of 519,000 people worldwide. Many cancer genes are posttranscriptionally regulated by RNA-binding proteins (RBPs) and microRNAs. The RBP HuR binds ... -
Performancee evaluation of a dual Micro-SPECT detector system [abstract]
Walters, Andrew; Daibes Figueroa, Said, 1977-; Rold, Tammy L.; Hoffman, Timothy Joseph, 1958- (University of Missouri--Columbia. Office of Undergraduate Research, 2006)The ability to conduct radiopharmaceutical research in vivo is largely dependent on nuclear imaging hardware and is subject to its limitations. The inability of clinical instrumentation to conduct non-invasive tracer ... -
Production and optimization of 198/199 gold nanoparticles for potential use in cancer therapy [abstract]
Rahing, Valerie; Kan, Para, 1980-; Hoffman, Timothy Joseph, 1958-; Kannan, Raghuraman; Katti, Kattesh V.; Cutler, Cathy S. (University of Missouri--Columbia. Office of Undergraduate Research, 2007)Radiopharmaceuticals are used to diagnose and treat a number of diseases such as bone cancer and non-Hodgkin's lymphoma. A radiopharmaceutical typically consists of a targeting molecule that selectively targets certain ... -
Targeting the BB2 receptor on human prostate cancer cells using Indium-111 labeled radiopharmaceutical [abstract]
Naz, Farah; Garrison, Jered C.; Rold, Tammy L.; Sieckman, Gary; Carter, Sara; Bell, N. R.; Daibes Figueroa, Said, 1977-; Walters, Andrew; Hoffman, Timothy Joseph, 1958- (University of Missouri--Columbia. Office of Undergraduate Research, 2006)The BB2 receptor, belonging to the Bombesin receptor family, has been shown to be highly over expressed in a variety of cancer cell lines, including human prostate cancer. Over expression of the BB2 receptor offers an ... -
Targeting the bombesin subtype 2 receptor for the diagnosis and treatment of metastatic prostate cancer
Manuel, Christopher Aaron, 1977- (University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In the United States, prostate cancer is the most commonly diagnosed cancer and the third leading cause of cancer related deaths in men. With early ... -
Using Indium-111 labeled radiopharmaceuticals to target the BB2 receptor on human prostate cancer cells [abstract]
Naz, Farah; Garrison, Jered C.; Rold, Tammy L.; Sieckman, Gary; Carter, Sara; Bell, N. R.; Figueroa, Said Daibes; Walters, Andrew; Hoffman, Timothy Joseph, 1958- (University of Missouri--Columbia. Office of Undergraduate Research, 2007)The BB2 receptor, belonging to the Bombesin receptor family, has been shown to be highly over expressed in a variety of cancer cell lines, including human prostate cancer. Our laboratory have been involved, for over a ...