Browsing by Author/Contributor "Ibdah, Jamal A."
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The effect of aldosterone on fatty acid oxidation in HepG2 cells [abstract]
Pineda, Juan Camilo; Ibdah, Jamal A.; Clark, Suzanne E.; Thyfault, John P.; Szary, Nicholas M. (University of Missouri--Columbia. Office of Undergraduate Research, 2008)The HepG2 cell line is an immorilized cell line harvested from a human hepatocellular carcinoma. This study is designed to investigate the affect of aldosterone on the mitochondrial function, specifically fatty acid ... -
Interdisciplinary Approach to Examine the Effects of Lifestyle Modifications on Nonalcoholic Fatty Liver Disease
Rector, R. Scott (Randy Scott); Uptergrove, Grace M.E.; Booth, Frank W., Ph. D.; Thyfault, John P.; Ibdah, Jamal A. (2010)A critical complication of the obesity epidemic experienced in Westernized societies is nonalcoholic fatty liver disease (NAFLD). NAFLD, fatty liver not due to alcohol consumption, is the most common chronic liver disease ... -
Intrinsic high aerobic capacity protects against lipid induced hepatic insulin resistance [abstract]
Morris, E. Matthew; Uptergrove, Grace M.E.; Koch, Lauren; Britton, Steve L.; Ibdah, Jamal A. (2010)Hepatic steatosis is commonly linked to hepatic insulin resistance. However, recent studies have found that increased hepatic triacylglycerol (TAG) accumulation is not always associated with impaired hepatic insulin ... -
Mineralocorticoid receptor antagonism attenuates vascular apoptosis and injury via rescuing protein kinase B activation
Wei, Yongzhong; Whaley-Connell, Adam T.; Habibi, Javad, 1947-; Rehmer, Jenna; Rehmer, Nathan; Patel, Kamlesh D.; Hayden, Melvin; DeMarco, Vincent G.; Ferrario, Carlos M.; Ibdah, Jamal A.; Sowers, James R. (James Russell), 1942- (American Heart Association, 2008)Emerging evidence indicates that mineralocorticoid receptor (MR) blockade reduces the risk of cardiovascular events beyond those predicted by its blood pressure-lowering actions; however, the underlying mechanisms remain ... -
Outcome of medical versus surgical therapies for gastroesophageal reflux disease : meta analysis of randomized controlled trials [abstract]
Winn, Jessica; Choudhary, Abhishek; Arif, Murtaza; Szary, Nicholas M.; Chauhan, Lakshmi; Grewal, Ajitender; Hammoud, Ghassan M.; Bechtold, Matthew L. (2010)Gastroesophageal Reflux Disease is one of the most common chronic gastrointestinal tracts. Medical management includes use of antisecretory medications or surgical management. Randomized controlled trials have compared ... -
Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic ren2 rats
Wei, Yongzhong; Clark, Suzanne E.; Thyfault, John P.; Uptergrove, Grace M.E.; Wenhan, Li; Whaley-Connell, Adam T.; Ferrario, Carlos M.; Sowers, James R. (James Russell), 1942-; Ibdah, Jamal A. (American Society for Investigative Pathology, 2009)Emerging evidence indicates that impaired mitochondrial fatty acid [beta]-oxidation plays a key role in liver steatosis. We have recently demonstrated that increased angiotensin (ANG) II causes progressive hepatic steatosis ... -
PGC-1[alpha] overexpression in primary hepatocytes increases fatty acid oxidation and mitochondrial content [abstract]
Khan, Mahir; Morris, E. Matthew; Uptergrove, Grace M.E.; Thyfault, John P. (2010)The role of peroxisome proliferator-activated receptor-[gamma] coactivator-1[alpha] (PGC-1[alpha]) in increasing mitochondrial content and fatty acid oxidation (FAO) in skeletal muscle has been well described. Often, this ... -
Translational Approach to Examine the Importance of Aerobic Fitness on Nonalcoholic Fatty Liver Disease [abstract]
Morris, E. Matthew; Rector, R. Scott (Randy Scott); Britton, Steve L.; Ibdah, Jamal A.; Thyfault, John P. (2010)Low cardiorespiratory fitness, independent of physical activity levels, is the best predictor of early mortality and is linked to type 2 diabetes and CVD. In the absence of exercise training, it is believed that genetic ... -
Translational medicine: from discovery to health
Ibdah, Jamal A. (University of Missouri (System), 2010-03)Jamal Ibdah spoke on the topic "National Movement of Clinical and Translational Science and Drug Discovery." -
Two-stage vs. single-stage management of patients with choledocholithiasis : meta analysis of randomized controlled trials [abstract]
Choudhary, Abhishek; Winn, Jessica; Arif, Murtaza; Szary, Nicholas M.; Grewal, Ajitender; Hammoud, Ghassan M.; Bechtold, Matthew L. (2010)Current management of choledocholithiasis involves two stage process involving ERCP and laparoscopic cholecystectomy (LC). An alternative single-stage laparoscopic treatment was introduced for these patients. Various ...