Browsing by Author/Contributor "Lubahn, Dennis B. (Dennis Bryant), 1954-"
Now showing items 1-10 of 10
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Can diet influence cancer cell growth? Effects of phytoestrogens on the hedgehog-signaling pathway in prostate cancer [abstract]
Albert, Natalie; Sestric, Amy; Slusarz, Anna; Bogener, Jennifer; Lubahn, Dennis B. (Dennis Bryant), 1954- (University of Missouri--Columbia. Office of Undergraduate Research, 2007)Prostate cancer continues to be one of the most common cancers affecting American men. By better understanding the mechanisms involved in prostate cancer cell proliferation, better treatments can be developed and more cases ... -
Characterization of Esrrb function in metastatic prostate cancer cells and transcriptional regulation of hedgehog-signaling pathway target genes
Lu, Yuan (University of Missouri--Columbia, 2014)Orphan nuclear receptor Estrogen Receptor Related Receptor Beta (Esrrb) is a transcription factor. Although it was also shown to be important in cancer, little is known about its function in cancer cells and cancer relevant ... -
Characterization of SF-hERR[beta] repression of human estrogen receptor alpha and estrogen receptor-beta transcriptional activities
Liu, Jinghua, 1978- (University of Missouri--Columbia, 2009)Discovery of new ways to modulate estrogen actions through estrogen receptor is always exciting because of the importance of estrogen and ERs in many human diseases. In this dissertation, we report our discovery of the ... -
Development of a PCR assay to genotype aromatase knockout mice [abstract]
Noel, Cassandre; Bogener, Jennifer; Gallimore, Malaika; Lubahn, Dennis B. (Dennis Bryant), 1954- (University of Missouri--Columbia. Office of Undergraduate Research, 2007)The aromatase knockout mouse lacks the gene sequence coding for functional aromatase, a protein that converts androgens into estrogens. Previously, to genotype an aromatase mouse, two separate PCRs were run: #1) Neomycin ... -
Estrogen receptors in TRAMP C2 cells
Holland, Clifton; Liu, Jinghua, 1978-; Lubahn, Dennis B. (Dennis Bryant), 1954- (University of Missouri--Columbia. Office of Undergraduate Research, 2005)According to a 2005 study done by the American Cancer Society, prostate cancer is the second most common type of cancer among American men. It has been shown that estrogen receptors alpha and beta play significant roles ... -
Improving mouse-DMH screening capability by adding 2000 mouse CpG islands
Randall, Fellana L.; Beck, Katherine M.; Fischer, William C.; Zhuang, Yi; Slusarz, Anna; Lubahn, Dennis B. (Dennis Bryant), 1954- (University of Missouri--Columbia. Office of Undergraduate Research, 2004)DNA methylation alteration, in correlation with gene expression, is involved in development and progression of many cancers. Using a microarray based method, mouse-DMH (Differential Methylation Hybridization), our lab is ... -
Spinach, a cyclops, and the search for a cure for prostate cancer
Lucido, Kathryn; Drenkhahn, Sara K.; Ebone, John P.; Starkey, Nicholas J.; Liu, Jinghua, 1978-; Slusarz, Anna; Lubahn, Dennis B. (Dennis Bryant), 1954- (University of Missouri--Columbia. Office of Undergraduate Research, 2008)Other than skin cancer, prostate cancer is the most prevalent form of cancer in men. The likelihood of developing prostate cancer increases with age; so that nearly every male will die with some form of prostate cancer ... -
Studying DNA methylation changes of CpG islands in different stages of prostate cancer by pyrosequencing
Ladd, Eric; Zhuang, Yi; Burks, Amos; Slusarz, Anna; Lubahn, Dennis B. (Dennis Bryant), 1954- (University of Missouri--Columbia. Office of Undergraduate Research, 2005)Prostate cancer is one of the most common forms of cancer in men. Our lab is currently investigating changes in DNA methylation that occur during cancer progression, and in response to the soy phytoestrogen genistein ... -
Use of simvastatin to inhibit advanced prostate cancer formation in the TRAMP mouse model of prostate cancer
Drenkhahn, Sara K., 1985- (University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] A provocative question currently proposed by the NIH is: do statin medications, which lower serum cholesterol, prevent cancer? We hypothesize that ... -
The utility and limitations of the TRAMP model system for studying the effects of hedgehog targeted therapy in prostate cancer
Jackson, Glenn A. (University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Advanced prostate cancer has a very poor prognosis and no curative therapies. Understanding of the hedgehog (Hh) signaling pathway, a potential target ...