Browsing by Author/Contributor "McClellan, Andrew"
Now showing items 1-19 of 19
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Anatomical organization of locomotor command systems in the lamprey brain [abstract]
Luan, Lucia; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2007)In vertebrates, command systems in the brain activate central pattern generators (CPGs) in the spinal cord to generate the basic pattern of locomotor activity, such as swimming or walking. Reticulospinal (RS) neurons in ... -
Axonal regeneration following spinal cord hemi-transection in larval lamprey
Santoli, Josh; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2008)In higher vertebrates, including humans, axonal regeneration following spinal cord injury (SCI) is very limited and there is little behavioral recovery. In contrast, lower vertebrates, such as lamprey, fish, and certain ... -
Changes in properties of lamprey reticulospinal neurons following spinal cord injury
Pale, Timothee (University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The lamprey is one of the most ancient vertebrates, sharing many of basic characteristics of the brain and spinal cord with higher, more evolved ... -
Effects of axotomy on calcium influx in reticulospinal neurons of larval lamprey [abstract]
Cozad, Matthew; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2007)The lamprey is a prime example of the remarkable axonal regeneration that can occur in lower vertebrates. Previous studies showed that spinal cord transected lamprey recover normal locomotor behavior in about 8 weeks ... -
The effects of axotomy on the biophysical properties of reticulospinal neurons in larval lamprey
Benes, Jessica Anne (University of Missouri--Columbia, 2006)Following severe spinal cord injury (SCI), in adult higher vertebrates there is little or no axonal regeneration, and animals remain paralyzed below the lesion. In contrast, lower vertebrates such as the lamprey, following ... -
Evidence that glutamate induced neurite retraction of reticulospinal neurons is dependent on calcium influx
Patel, Anjali; Shotts, Lindsay; Ryan, Sarah Kathleen; Marsh, Georgia; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2004)Locomotor systems of vertebrates consist of a command system in the brain that activates central pattern generators in the spinal cord to initiate locomotor behavior. Reticulospinal (RS) neurons are the output neural ... -
Factors that affect the degree of axonal regeneration following spinal cord transection in larval lamprey
Donley, Jeffrey; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2004)In all vertebrate animals, reticulospinal (RS) neurons in a locomotor “command” systems in the brain send neural processes to the spinal cord to activate “central pattern generators” (CPGs) and initiate locomotor behavior. ... -
Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
Ryan, Sarah Kathleen (University of Missouri--Columbia, 2005)In spinal cord-transected larval lamprey, descending brain neurons, most of which are reticulospinal (RS) neurons, regenerate their axons across a transection site and contribute to behavioral recovery. In the present ... -
Imaging reticulospinal neurons in the lamprey brainstem using calcium indicator
Jouret, Jill; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2005)Imaging reticulospinal neurons in the lamprey brainstem using calcium indicator In the lamprey, a lower vertebrate, reticulospinal (RS) neurons in the brain are the output elements of the command system that activate spinal ... -
The mechanism by which potassium causes neurite retraction in lamprey descending neurons in cell culture
Le, MyChi; Ryna, Sarah; Shotts, Lindsay; Marsh, Georgia; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2004)Severe spinal cord injury (SCI) disrupts descending axons from reticulospinal (RS) neurons that project to the spinal cord. In most “higher” vertebrates, including humans, recovery is very minimal due to limited regeneration ... -
Neuronal changes underlying altered biophysical properties of reticulospinal neurons following spinal cord injury in the lamprey
Hough, Ryan Anthony (University of Missouri--Columbia, 2017)Following a severe spinal cord injury (SCI), the descending axons of reticulospinal (RS) neurons are damaged, resulting in paralysis below the site of the injury. For higher vertebrates, including humans, RS neurons are ... -
Organization and repair of the trigeminal system in the lamprey using fluorescent double labeling [abstract]
Ko, Ka Yu; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2006)In the CNS, many sensory and motor systems are topologically organized relative to various body structures. For example, in humans, sensory inputs from the lower, middle, and upper parts of the body are received by the ... -
Organization of brain and spinal cord locomotor networks in larval lamprey
Jackson, Adam Wesley (University of Missouri--Columbia, 2006)In vertebrates, brain locomotor command systems activate spinal central pattern generators (CPGs) to initiate locomotor behavior. The size and pharmacology of brain command systems are unknown, and the movements that result ... -
Organization of the command system in the lamprey brain that initiates locomotor behavior
Iyamu, Michael; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2004)In vertebrate animals, the muscle activity pattern for locomotor behavior is produced by central pattern generators (CPGs) in the spinal cord. In the brain, “command” systems, which have several levels, process information ... -
Recovery of locomotor function following spinal cord hemi-transections in larval lamprey [abstract]
Hargis, Sarah; St. Paul, Alison; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2007)In vertebrates, reticulospinal (RS) neurons in the brain activate spinal motor networks to initiate locomotor behavior. Following spinal cord injury (SCI), RS neurons no longer communicate with the spinal cord, and animals ... -
Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey
Kovalenko, Mykola (University of Missouri--Columbia, 2008)After spinal cord injury in larval lamprey, RS neurons regenerate their axons (Davis and McClellan, 1994a,b), restore synaptic contacts and most of the original locomotor functions (McClellan, 1998). It was previously ... -
Test of the half-center model for locomotor activity in adult lamprey spinal cord [abstract]
St. Paul, Alison; Hargis, Sarah; McClellan, Andrew (University of Missouri--Columbia. Office of Undergraduate Research, 2007)Rhythmic motor behaviors, such as locomotion, chewing, scratching, copulation, and communication, are critical for survival. In all animals, rhythmic motor activity is produced by central patterns generators (CPGs) which ... -
Topological organization of the trigeminal system in the lamprey and restoration following axonal regeneration
Ly, Lexie ToLoan (University of Missouri--Columbia, 2012)The nervous systems of lower vertebrates, such as the lamprey, share many of the basic features of the brain and spinal cord of higher vertebrates. However, unlike humans and other higher vertebrates, the lamprey displays ... -
Using simple nervous systems to investigate the neural basis of behavior
McClellan, Andrew; Schul, Johannes; Schulz, David; Zars, Troy Daniel (2010)The human brain is remarkable, both in the sense that it helps us with a lifetime of decisions and memories, but also that it allows us to contemplate how the brain itself works. One concludes, however, pretty quickly ...