Browsing by Author/Contributor "Sun, Grace Y."
Now showing items 1-13 of 13
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Activation of astrocytes: involvement of NADPH oxidase and cytosolic phospholipase A2
Hu, Chunhua (University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Reactive oxygen species (ROS) are produced in cells by enzymic and non-enzymic mechanisms and play important roles in the pathogenesis of neurodegenerative ... -
Amyloid beta induces cPLA2 activation by an NADPH oxidase-dependent mechanism in neurons
Shelat, Phullara B., 1978- (University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Alzheimer's disease (AD) is a neurodegenerative disorder affecting more than 20 million people worldwide. An increase in production of amyloid beta ... -
Amyloid-beta toxicity in neurons and potential botanical compounds for prevention of Alzheimer's disease
He, Yan, 1979- (University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Alzheimer's disease (AD) is characterized by a progressive decline in memory and cognitive function together with increased oxidative stress in the ... -
Antioxidants to combat Alzheimer's disease
Phillips, Laura; Simonyi, Agnes; Sun, Grace Y. (University of Missouri--Columbia. Office of Undergraduate Research, 2008)Alzheimer's disease (AD) took the life of my grandfather. It is believed that oxidative stress contributes to the progression of this disease. Studies in Dr. Sun's laboratory recognized NADPH oxidase as possible source for ... -
An assessment on resveratrol and its cellular protective properties
Han, Dongdong; Simonyi, Agnes; Sun, Grace Y. (University of Missouri--Columbia. Office of Undergraduate Research, 2008)Resveratrol is a polyphenolic compound found abundantly in plants such as knotweed or grapes. Under normal circumstances, it is in plants as a phytoalexin - an antibiotic produced by plants for defense under insults. Based ... -
Aβ toxicity to SHSY-5Y human neuroblastoma cells
Johnson, Omega; Shelat, Phullara B., 1978-; Simonyi, Agnes; Sun, Grace Y. (University of Missouri--Columbia. Office of Undergraduate Research, 2005)Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in the loss of memory, language deterioration, confusion, restlessness, and eventually destroyed cognition. It is characterized by an ... -
Differential effects of grape seed extract on inflammatory responses of microglial cells [abstract]
Nielsen, Paul; Sun, Grace Y. (University of Missouri--Columbia. Office of Undergraduate Research, 2007)Microglial activation has been linked to multiple pathologies, including Alzheimer's disease and cerebral ischemia. Nitric oxide (NO) production by inducible nitric oxide synthase (iNOS) and superoxide from NADPH oxidase ... -
Green tea epigallocatechin-3-gallate (EGCG) inhibits cytokine-induced nitric oxide and secretory phospholipase A2-IIA in glial cells [abstract]
Mohammad, Arwa; Sheng, Wenwen (2010)Glial cells, including astrocytes and microglial cells, are activated in response to injury and neurodegenerative diseases. In culture studies, astrocytes and microglial cells are capable of responding to proinflammatory ... -
Oxidative stress alters cell morphology and cell death indices in immortalized astrocytes
Morrissey, Jenny; Zhang, Xiaolin; Sun, Grace Y. (University of Missouri--Columbia. Office of Undergraduate Research, 2004)Menadione, usually known as vitamin K3, also serves as a trigger for oxidative stress, delivering reactive oxygen species (ROS) upon entering the cells. Astrocytes are glial cells that are found in the brain and are extremely ... -
The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
Chuang, Dennis Yi-Lun, 1985- (University of Missouri--Columbia, 2016)Oxidative and nitrosative stress is known to play an important role in neurodegenerative and neuroinflammatory diseases, such as Alzheimer's disease, Parkinson's disease, ischemic[slash]hemorrhagic stroke, and traumatic ... -
ROS from menadione induces astrocytic damage: protective effects of apocynin
Wang, Xiaowen; Sheng, Vivien; He, Yan, 1979-; Simonyi, Agnes; Sun, Grace Y. (University of Missouri--Columbia. Office of Undergraduate Research, 2008)Oxidative stress is a core cause of neurodegenerative diseases such as Alzheimer's disease. When cells are under oxidative stress, they will produce a high amount of reactive oxygen species (ROS). ROS are small and highly ... -
Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes
Jensen, Michael D., 1979- (University of Missouri--Columbia, 2009)Alzheimer's disease (AD) is a progressive, fatal neurodegenerative disease marked with dementia. Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to have a role in the pathogenesis of multiple ... -
Tnf[alpha] alters occludin and endothelial cell barrier function : role of p38MAPK
Ni, Yawen (University of Missouri--Columbia, 2016)Occludin is one of the key tight junction (TJ) proteins in endothelial cells and it plays an important role in modulating blood brain barrier (BBB) function. This protein (65kDa) has been shown to engage in many signaling ...