Browsing by Author/Contributor "Thyfault, John P."
Now showing items 1-20 of 20
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Changes in fatty acids profiles after three weeks of high-fat diet feeding in obesity-prone rats
Liu, Tzu-Wen (University of Missouri--Columbia, 2013)High-fat diet (HFD) feeding is commonly used in animal models to induce obesity and metabolic diseases. However, the effect of HFD on serum fatty acid profiles remains unclear. Changes in serum fatty acid profiles due to ... -
The effect of aldosterone on fatty acid oxidation in HepG2 cells [abstract]
Pineda, Juan Camilo; Ibdah, Jamal A.; Clark, Suzanne E.; Thyfault, John P.; Szary, Nicholas M. (University of Missouri--Columbia. Office of Undergraduate Research, 2008)The HepG2 cell line is an immorilized cell line harvested from a human hepatocellular carcinoma. This study is designed to investigate the affect of aldosterone on the mitochondrial function, specifically fatty acid ... -
The effects of exercise and omega-3 fatty acid supplementation as treatments for hepatic steatosis
Borengasser, Sarah Jean, 1978- (University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The purpose of this study was to examine the individual and combined effects of exercise and dietary consumption of n3PUFAs as treatments for NAFLD. ... -
Effects of statins on metabolic adaptations to aerobic exercise training : preliminary findings [abstract]
Boyle, Leryn J.; Mikus, Catherine R.; Ruebel, Meghan L.; Fadel, Paul J.; Thomas, Tom R.; Laughlin, M. Harold (2010)Emerging evidence suggests statins, unlike exercise, may cause deleterious effects on skeletal muscle oxidative capacity and insulin sensitivity. The purpose of this study was to determine if daily statin therapy altered ... -
Endurance or sprint interval exercise, & metformin treatment differently modify insulin-induced vasodilation in skeletal muscle arterioles of obese insulin resistant rats
Crissey, Jacqueline M.; Padilla, Jaume; Jenkins, Nathan T.; Thyfault, John P.; Laughlin, M. Harold (2012)A key contributor to insulin-mediated glucose uptake is insulin-induced vasodilation of skeletal muscle arterioles, which is impared with obesity and Type 2 diabetes (T2D). Abnormalities in the vascular reactivity to insulin ... -
Exercise and glycemic control in individuals with type 2 diabetes
Oberlin, Douglas J. (University of Missouri--Columbia, 2011)Type 2 diabetes (T2D) and the associated impaired glycemic control greatly increases the risk of cardiovascular disease mortality. PURPOSE: It is unknown if or for how long a single bout of exercise will reduce post-prandial ... -
Exercise, FGF21, and PGC-1 : roles in hepatic metabolism
Fletcher, Justin Andrew (University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The liver is instrumental in maintaining euglycemia during times of fasting and exercise, and in-turn exercise is a stimulus that challenges the liver ... -
Insulin-mediated increases in arterial baroreflex control of muscle sympathetic nerve activity following meal intake in humans [abstract]
Vianna, Lauro C.; Young, Colin Neal, 1981-; Mikus, Catherine R.; Thyfault, John P. (2010)Animal studies indicate that insulin enhances arterial baroreflex (ABR) control of sympathetic nerve activity (SNA); however, the extent to which these findings can be extrapolated to humans is unknown. To begin to address ... -
Interdisciplinary Approach to Examine the Effects of Lifestyle Modifications on Nonalcoholic Fatty Liver Disease
Rector, R. Scott (Randy Scott); Uptergrove, Grace M.E.; Booth, Frank W., Ph. D.; Thyfault, John P.; Ibdah, Jamal A. (2010)A critical complication of the obesity epidemic experienced in Westernized societies is nonalcoholic fatty liver disease (NAFLD). NAFLD, fatty liver not due to alcohol consumption, is the most common chronic liver disease ... -
Intrinsic high aerobic capacity protects against lipid induced hepatic insulin resistance [abstract]
Morris, E. Matthew; Uptergrove, Grace M.E.; Koch, Lauren; Britton, Steve L.; Ibdah, Jamal A. (2010)Hepatic steatosis is commonly linked to hepatic insulin resistance. However, recent studies have found that increased hepatic triacylglycerol (TAG) accumulation is not always associated with impaired hepatic insulin ... -
Metabolic responses to a high fat diet in skeletal muscle of rats bred for high or low endurance running capacities
Naples, Scott (University of Missouri--Columbia, 2009)Whole body aerobic capacity and mitochondrial oxidative capacity are linked and may play an obligatory role in the maintenance of metabolic function and protection against insulin resistance when challenged with a high-fat ... -
Optimizing vascular and metabolic responses to insulin in type 2 diabetes : exercise as treatment
Mikus, Catherine R. (University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The vasodilatory effects of insulin typically account for up to 40% of insulin-mediated glucose disposal; however, insulin-stimulated vasodilation is ... -
Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic ren2 rats
Wei, Yongzhong; Clark, Suzanne E.; Thyfault, John P.; Uptergrove, Grace M.E.; Wenhan, Li; Whaley-Connell, Adam T.; Ferrario, Carlos M.; Sowers, James R. (James Russell), 1942-; Ibdah, Jamal A. (American Society for Investigative Pathology, 2009)Emerging evidence indicates that impaired mitochondrial fatty acid [beta]-oxidation plays a key role in liver steatosis. We have recently demonstrated that increased angiotensin (ANG) II causes progressive hepatic steatosis ... -
PGC-1[alpha] overexpression in primary hepatocytes increases fatty acid oxidation and mitochondrial content [abstract]
Khan, Mahir; Morris, E. Matthew; Uptergrove, Grace M.E.; Thyfault, John P. (2010)The role of peroxisome proliferator-activated receptor-[gamma] coactivator-1[alpha] (PGC-1[alpha]) in increasing mitochondrial content and fatty acid oxidation (FAO) in skeletal muscle has been well described. Often, this ... -
Physical inactivity rapidly alters glycemic control in young, lean, previously active volunteers [abstract]
Oberlin, Douglas J.; Mikus, Catherine R. (2010)Postprandial hyperglycemia is a better predictor of cardiovascular disease and all cause mortality than fasting blood glucose or hemoglobin A1c. Physical inactivity is associated with insulin resistance and cardiovascular ... -
A proposed scoring system for quantification of metabolic syndrome severity
Bollinger, Lance (University of Missouri--Columbia, 2008)Metabolic syndrome (MetS) is a significant risk factor for cardiovascular disease, type 2 diabetes, and mortality. Currently, there is no established tool to quantify severity of MetS. Furthermore, it is unclear which ... -
Short-term aerobic exercise training in type 2 diabetes
Kearney, Monica L. (University of Missouri--Columbia, 2015)Type 2 diabetes (T2D) is a worldwide problem, and people with T2D have impaired postprandial glycemia (PPG). While current pharmaceutical therapies are targeted to reduce glycosylated hemoglobin and may not be effective ... -
Translational Approach to Examine the Importance of Aerobic Fitness on Nonalcoholic Fatty Liver Disease [abstract]
Morris, E. Matthew; Rector, R. Scott (Randy Scott); Britton, Steve L.; Ibdah, Jamal A.; Thyfault, John P. (2010)Low cardiorespiratory fitness, independent of physical activity levels, is the best predictor of early mortality and is linked to type 2 diabetes and CVD. In the absence of exercise training, it is believed that genetic ... -
Vascular actions of insulin in cardiometabolic disease : effects of metformin, physical activity, and intrinsic aerobic fitness
Crissey, Jacqueline M., 1981- (University of Missouri--Columbia, 2013)Insulin has important vascular and metabolic actions. The vascular effects of insulin typically account for as much as 40-50% of insulin-stimulated glucose disposal. However, the vascular reactivity to insulin is impaired ... -
Vascular dysfunction and insulin stimulated blood flow : impact of physical inactivity and type 2 diabetes
Boyle, Leryn J. (University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Individuals with type 2 diabetes (T2D) have blunted femoral artery insulin mediated blood flow which is critical for the delivery and uptake of glucose ...