Browsing by Thesis Department "Biological engineering (MU)"
Now showing items 1-20 of 190
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Accurate DNA microsatellite and microRNA detection with a biological nanopore
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Nanopore-based detection has been used in many genetic, epigenetic, proteomic, and bio-mechanism studies. In this report, we introduced two ... -
Amyloid- [beta] peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A₂
(University of Missouri--Columbia, 2010)Oligomeric amyloid-[beta] peptide (A[beta]) is known to induce cytotoxic effects and damage cell functions in Alzheimer's disease. However, mechanisms underlying the effects of A[beta] on cell membranes have yet to be fully ... -
Applications of gel electrophoresis in quantum dot conjugates' separation and purification
(University of Missouri--Columbia, 2009)The objectives of this study were to build Quantum dot (QD) crosslinker complexes for antibody conjugation usage, to purify QD crosslinker complexes by gel electrophoresis and to check the biological functionalities of ... -
Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development
(University of Missouri--Columbia, 2010)For several decades, optical ring resonators have played an important role in the field of telecommunications. Within only the past decade however, ring resonators have been applied for the purposes of biological and ... -
Aptamer encoded nanopores as single molecule sensors
(University of Missouri--Columbia, 2008)We have created a low noise, calibrated, molecular-scaled pore. The nanopore is formed either by micro-forge polishing or external penetration of the nanocavity sealed in the pipette terminal. The nanopore fabrication is ... -
Assessing the biocompatibility of different sizes and concentrations of gold nanoparticles conjugated to decellularized tissue scaffolds
(University of Missouri--Columbia, 2016)Gold nanoparticles conjugated to decellularized scaffolds have been studied previously within the fields of tissue engineering and biomaterials. They hold much potential for applications in soft tissue repair and improved ... -
Atomic force microscopy (AFM) for measurement of cell elastic properties
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] This thesis presents data on the use of atomic force microscopy (AFM) for manipulating, detecting, and resolving the mechanical characteristics of ... -
Automated detection of amperometric spikes resulting from quantal exocytosis and estimation of spike and pre-spike foot signal parameters
(University of Missouri--Columbia, 2018)Electrochemical microelectrodes can detect single-vesicle release events as "spikes" of amperometric current. We developed a template based "matched-filter" approach that performs least squares fit of a library of templates ... -
Automatic four-limb IMU gait analysis in the canine DMD model
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Gait analysis is valuable for studying neuromuscular and skeletal diseases. Wearable motion sensors or inertial measurement units (IMUs) possess ... -
Azelnidipine attenuates inflammatory responses, siperoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells
(University of Missouri--Columbia, 2014)Alzheimer's disease (AD) is a debilitating neurodegenerative disease with no known cure. The cause and progression of AD is still unclear. Over the years, studies have shown that one of the earliest cytotoxic effects is ... -
Between-row mower design for weed control in organically grown no-till soybeans
(University of Missouri--Columbia, 2018)Weeds are a major challenge in organic no-till soybean production. They impair crop growth and result in yield loss. Innovative weed control methods need to be developed and experimented with in organic no-till agriculture ... -
Biophysical and photobiological modulations of cellular pathways in Alzheimer's disease
(University of Missouri--Columbia, 2010)The overall goal of this thesis work is to study the effects of biomodulations on Alzheimer's disease (AD) related cellular pathways, using biophysical and photobiological methods, including secretory phospholipase A2, ... -
CCVJ's fluorescence lifetime as a viscosity measurement tool and its possible application as a tunable picoseconds reference lifetime standard
(University of Missouri--Columbia, 2007)9-(2-carboxy-2-cyanovinyl) julolidine (CCVJ, a molecular rotor) was shown to perform as a viscosity sensitive probe. Using steady state spectroscopy, CCVJ was shown to have decreased emission intensity as the environmental ... -
CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) underlie the lethal genetic disease cystic fibrosis. Although CFTR belongs ... -
Characterization [of] nucleic acids unwinding and exploring its application in miRNA detection in the nanopore
(University of Missouri--Columbia, 2012)MicroRNAs (miRNAs) are a class of short (~14-27 nucleotides) noncoding RNAs that regulate gene expression at the post-transcriptional level. Aberrant expression of miRNAs has been found in all types of tumors. Reverse ... -
Characterization of membrane viscosity changes with the novel molecular rotor FCVJ
(University of Missouri--Columbia, 2007)Membrane viscosity can be defined as the "thickness" of a cell membrane. Membrane viscosity conditions are a useful indicator of cell health. Many diseases have been reported to induce changes in afflicted cell membrane ... -
Characterizing optical properties in fibrous tissues
(University of Missouri--Columbia, 2011)Optical methods are promising for non-invasive tissue characterization. Biological tissues can be classified into isotropic tissues and anisotropic tissues. The optical properties of isotropic tissues such as adipose tissue ... -
Climate and land use effects on hydrologic processes and water allocation in a primarily rain-fed, agricultural watershed
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] There is a need to raise our understanding of the impact of climate variability and change on hydrologic processes at the watershed scale. This is ... -
Climate change impacts on hydrologic components and occurrence of drought in an agricultural watershed
(University of Missouri--Columbia, 2018)The study on potential acceleration of future hydrologic cycle due to change in precipitation and increase in temperature are essential for managing natural resources and setting policy. The impact of future climate change ... -
Clinical translation of nanomaterials for early detection of genetic abnormalities in fetus and retinopathy in neonates and adults
(University of Missouri--Columbia, 2017)Nuclear medicine covers a wide variety of radionuclides to meet demands of disease. In the current study, first we have looked at the application of mono-amine mono-amide ligands for Re(V), 99mTc(V), and 186Re(V) with ...