Browsing by Thesis Department "Medical pharmacology and physiology (MU)"
Now showing items 1-20 of 26
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The absorption of fat by the mammalian stomach
(University of Missouri--Columbia, 1913)A proper analysis of the function of the stomach in alimentation involves not only those factors which produce chemical and mechanical changes in the foods during its stay in the gastric cavity; but also, the extent to ... -
The action of Digitalis on the cardiac inhibitory centre
(University of Missouri--Columbia, 1914)So long has digitalis been in use as a clinical drug and so long has its action been the subject of experimentation that it would seem that there is little hope of presenting anything new on the subject. Yet so long as ... -
Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm and atherosclerosis
(University of Missouri--Columbia, 2021)The main focus of this dissertation is the role of Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm (AAA) and atherosclerosis. This first chapter of this document presents a review ... -
Cardiorespiratory abnormalities in early and advances stage mouse models of Duchenne muscular dystrophy
(University of Missouri--Columbia, 2021)Duchenne muscular dystrophy (DMD) is an X-linked severe muscle disease caused by dystrophin gene mutations affecting 1 in 3,500 newborn males worldwide every year. DMD is characterized by progressive skeletal muscle ... -
Contribution of TRPV4 to enhanced calcium cycling and cardiac arrhythmia following ischemia-reperfusion in aged mouse hearts
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Cardiomyocyte Ca2+ homeostasis is altered with aging and predisposes the Aged heart to Ca2+ intolerance and arrhythmia. Transient Receptor ... -
Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
(University of Missouri--Columbia, 2017)T2DM is a chronic disease characterized by low-grade inflammation in adipose tissue. Recent investigations have shown that a variety of immune cells can accumulate in adipose tissue contributing to the development of chronic ... -
The determination of the lecithans in the tissues and fluids of the animal body
(University of Missouri--Columbia, 1905)The Hoppe-Seyler method not offering a means of separation of the lecithins from the kephalins was not experimentally investigated. In attempting to apply the method of Koch to other tissues than the brain and spinal cord, ... -
The effect of digitalis on the cardiac peripheral neuro-muscular complex
(University of Missouri--Columbia, 1914)The question of the action on the animal organism of the principles found in the leaves and flowers of Digitalis purpurea has long been one of absorbing interest. A glance at the long list of articles dealing with researches ... -
The fat and lipase content of the blood following fat feeding and during increased muscular work
(University of Missouri--Columbia, 1917)Summary: 1. The fat content of the blood inoreases after a meal rich in cotton seed oil fat. 2. Cotton seed oil fat is more slowly digested than cream fat. 3. The lipase content of the blood increases after a meal of cotton ... -
The fat and lipase content of the liver
(University of Missouri--Columbia, 1915)The object of this thesis is to ascertain if any broad correlation exists between the lipase content of an organ and its state of fat metabolism. The author has chosen the liver as an organ, with its lipase content and fat ... -
Functional recovery of the microcirculation during skeletal muscle regeneration
(University of Missouri--Columbia, 2018)Skeletal muscle has a remarkable capacity to regenerate following injury, and although muscle regeneration has been studied extensively, little is known about the recovery of the skeletal muscle microcirculation during ... -
Integrin adhesion response to chemical and mechanical stimulation
(University of Missouri--Columbia, 2017)It is well recognized that arterial stiffness increases with aging and aging-related diseases, such as hypertension. The mechanisms for the increase in stiffness have been largely thought to be the result of changes in the ... -
Mechanisms for chlorinated lipids in sepsis
(University of Missouri--Columbia, 2020)Sepsis induces the formation of proinflammatory chlorinated lipids, stimulates adhesive interactions between the endothelium and leukocytes/platelets, causes mast cell activation, disrupts the microvascular barrier and ... -
Molecular mechanisms of action for CFTR potentiators
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As the culprit behind cystic fibrosis (CF) is the dysfunction of the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR), ... -
Molecular regulation of sarcomere function
(University of Missouri--Columbia, 2021)Molecular regulation of striated muscle contraction is widely thought to be regulated through canonical thin filament mechanisms, i.e., Ca2+ activation of thin filaments. Dual filament regulation is a novel model of striated ... -
On the pharmacological action of certain organic derivatives of arsenic with special reference to salvarsan and sodium cacodylate
(University of Missouri--Columbia, 1913)Since the introduction of Salvarsan by Ehrlich in the latter part of 1910 many facts have been brought out concerning its reactions in the body. The most important of these pharmacologically are the deaths which have been ... -
Pharmacological action of acetanilide, antipyrine & acetphenetidin on cardiac muscle
(University of Missouri--Columbia, 1911)It is a well-known fact that acetanilide and the antipyrine series, when administered in clinical cases, for antipyretic purposes, often have untoward and unexpected accompanying actions. These associated influences have ... -
Pharmacological action of atropine on cardiac muscle
(University of Missouri--Columbia, 1911)Does Atropine influence the cardiac rhythm and the power of the heart's contractions by direct action on its muscular tissue, and if so, to what extent and under what conditions? It is my purpose therefore in this work to ... -
The pharmacological action of certain bromide salts
(University of Missouri--Columbia, 1913)The purpose of the work on which this paper is based has been to study the effects of some of the bromide salts upon the isolated heart of a frog as revealed by substituting the bromides of potassium, sodium, and calcium ... -
Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)Background: N1303K, one of the common, severe disease-causing mutations in the CFTR gene, causes both defective biogenesis and gating abnormalities of the CFTR protein. The goals of the present study are to quantitatively ...