Browsing by Thesis Department "Microbiology (Medicine) (MU)"
Now showing items 1-20 of 72
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Activation and evasion of innate immune signaling pathways by Yersinia pestis /
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Yersinia pestis is a bacterial pathogen that causes the disease plague in mammals. The disease is rapidly lethal and infected individuals can succumb ... -
Alternative RNA processing and strategies to modulate splicing
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is a genetic disease that is intrinsically linked to an alternative RNA splicing event that leads a defective protein. ... -
Alternative translation and alternative RNA processing mechanism in parvovirus RNA processing
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Viruses as obligate intracellular metabolic parasite require the capacity to orchestrate and modulate the host environment either in the nucleus or ... -
Amplifying peripheral tolerance in type 1 diabetes through regulatory T cells and inhibitory Fc receptors
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Type I Diabetes (TID) is a devastating autoimmune disorder in which autoreactive T cells attack the insulin-producing [beta] cells in the pancreatic ... -
Analysis of interactions between the germline RNA helicases (GLHs) and their regulators KGB-1 and CSN-5 in Caenorhabditis elegans
(University of Missouri--Columbia, 2006)The Caenorhabditis elegans germline RNA helicases (GLHs) are constitutive components of P granules, non-membranous aggregates of protein and RNA that segregate with the nematode germline. The GLHs are critical for fertility. ... -
Biochemical characterization of clade B and non-B HIV-1 reverse transcriptase
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Two classes of drugs: nucleos(t)ide reverse transcriptase inhibitors (NRTIs) and non-nucleoside RT inhibitors (NNRTIs) target HIV-1 RT, an enzyme ... -
Cell-to-cell infection, cell-cell fusion and production of ebolavirus : mechanisms of action and cellular modulators
(University of Missouri--Columbia, 2016)Ebolavirus (EBOV), a member of the Filoviridae family, is a deadly non-segment negative-sense RNA virus that causes hemorrhagic fever among human and other species; the fatality rate can be up to 80%. In 2014, a re-emergent ... -
The cellular and humoral immune response against primary infection with Coxiella burnetii
(University of Missouri--Columbia, 2016)Coxiella burnetii infection in mice results in a limited febrile illness that can be measured by examining splenomegaly, bacterial burden, and histopathology. In humans, this disease is known as Q fever. Using the mouse ... -
The cellular immune response to murine lyme borreliosis
(University of Missouri--Columbia, 2015)Lyme disease is caused by the bacterial spirochete Borrelia burgdorferi. There are approximately 300,000 new cases of Lyme Disease reported in the United States each year. Individuals with Lyme disease often suffer from ... -
Characterization of cellular pathways in spinal muscular atrophy
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is an autosomal recessive genetic disease, and is the leading genetic cause of death in infants. SMA is a severe ... -
Characterization of HIV-1 reverse transcriptase drug resistance connection subdomain mutation N348I
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Connection subdomain mutations are a recently discovered class of reverse transcriptase (RT) drug resistance mutations which are positioned at some ... -
Characterization of the non-structural proteins of adeno-associated virus (AAV) and minute virus of canine (MVC)
(University of Missouri--Columbia, 2012)Parvoviruses are among the smallest of the animal DNA viruses. Due to their compact genome, these viruses display immense heterogeneity both in the mechanisms involved in gene expression and the functions of the encoded ... -
Characterization of the role of adenovirus-5 (Ad-5) gene products E2A, E4ORF6 and VA RNA on adeno-associated virus type 5 (AAV5) transcription, translation and replication
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] AAV5 is the most distinct serotype of the AAVs differing from the prototype virus AAV2 at the nucleotide level. We show that in AAV5 the Rep transcripts ... -
Characterization of the role of the DNA damage response pathway in parvoviral replication
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] We report that low multiplicity infection with the autonomous parvovirus minute virus of mice (MVM) results in the activation of a DNA damage response ... -
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity
(University of Missouri--Columbia, 2013)Retroviral compatibility with diverse glycoproteins has been known and identified through the course of several studies. However, molecular mechanisms of glycoprotein acquisition are poorly defined. Glycoproteins are ... -
Delineation of Duchenne muscular dystrophy gene therapy using genetically engineered mice
(University of Missouri--Columbia, 2016)Duchenne muscular dystrophy (DMD) is a genetically inherited debilitating muscle disorder affecting young boys due to the loss of dystrophin protein in muscle and the heart. Affected individuals lose their mobility and ... -
Dendritic cells, IL-12Rbeta2, and IL-13Ralpha1 signaling: the battle for control of neonatal immunity
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Newborns are highly susceptible to microbial infections and allergic reactions. This susceptibility is due to a lack of Th1 cells and an excess of Th2 ... -
Development of genome-wide genetic assays in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2015)Illumina sequencing and other massively-parallel, short read sequencing technologies have become prevalent methods for querying the genetic systems of organisms. This trend was initially driven by the demand for general ... -
Dicer interacts with the P-granule component GLH-1 : both localize to C. elegans nuclear pores and to stress-induced oocyte RNP granules
(University of Missouri--Columbia, 2010)P granules are ribonucleoprotein complexes specific to the cytoplasmic side of the nuclear pores of C. elegans germ cells. While P granules are implicated in post-transcriptional control of maternally-transcribed mRNAs, ... -
The effects of toll-like receptor ligand-activated dendritic cells on human CD4⁺T cell responses
(University of Missouri--Columbia, 2008)Dendritic cells (DCs) play an important role as a link between innate and adaptive immunity through their abilities to detect infection and to prime naïve T cells (signal 1 and 2). They not only activate naïve T cells, ...