Browsing by Thesis Department "Neuroscience (MU)"
Now showing items 1-20 of 27
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Analysis of the Caenorhabditis elegans rpc-1 gene
(University of Missouri--Columbia, 2005)In eukaryotes, two large subunits form the core catalytic structure of RNA polymerase III (Pol III), which is conserved in other RNA polymerases, Pol I and Pol II. It has been found that Pol III activity is tightly associated ... -
Associations between psychophysiological, immune, endocrine, and serotonergic biomarkers of stress and gastrointestinal symptoms in autism spectrum disorder
(University of Missouri--Columbia, 2016)Autism spectrum disorder (ASD) is often accompanied by gastrointestinal (GI) disturbances, which also may impact behavior. Alterations in autonomic, endocrine, and immune system functioning are also frequently observed in ... -
Canine degenerative myelopathy : perspectives from aging, microglia and neurofilaments
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Canine degenerative myelopathy (DM) is a late-onset neurodegenerative disease similar to some forms of amyotrophic lateral sclerosis (ALS). Mutations ... -
Clinical interventions for HIV-associated neurocognitive disorder (hand) : a systematic review
(University of Missouri--Columbia, 2020)Despite the widespread use of antiretroviral therapy, HIV-associated neurocognitive disorder (HAND) continues to be one of the most common central nervous system (CNS) complications of human immunodeficiency virus (HIV), ... -
CNS effects of blood-borne relaxin on the paraventricular nucleus of the hypothalamus
(University of Missouri--Columbia, 2013)Pregnancy is characterized by increased blood volume and baseline sympathetic nerve activity, and profound cardiovascular adaptations. Relaxin (RLX), an ovarian hormone which is elevated in pregnancy, activates the subfomical ... -
Dietary inflammatory index in patients with Alzheimer's dementia compared to controls
(University of Missouri--Columbia, 2018)Alzheimer's dementia (AD) is a chronic neurodegenerative disease causing progressive memory loss, cognitive decline across numerous domains, and, eventually, loss of daily living activities. Mild cognitive impairment (MCI) ... -
Disease characterization and pre-clinical testing in canine models of the neuronal ceroid lipofuscinoses
(University of Missouri--Columbia, 2021)The neuronal ceroid lipofuscinoses (NCLs) are inherited lysosomal storage disorders characterized by intracellular accumulation of autofluorescent storage material and by progressive degeneration of neurons in the brain ... -
The effect of maternal genotype, prenatal stress, and perinatal diet in offspring behavior in an animal model of autism
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] While the etiology of autism spectrum disorders is unknown, it is thought that a combination of genetic and environmental factors contribute to the ... -
Effects of beta-adrenergic antagonism in autism spectrum disorder
(University of Missouri--Columbia, 2016)Effective treatments for individuals with autism spectrum disorder are lacking, especially when it comes to pharmacological intervention, which can be an important addition to behavioral therapy. Currently available agents ... -
Examination of biological factors that mediate the influence of physical activity on palatability driven feeding
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Palatability driven feeding- consuming food for pleasure, and voluntary physical activity are mediated by and influence similar neural mechanisms. ... -
Functional outcome and self-perceived overall health status following surgery to remove primary brain tumor
(University of Missouri--Columbia, 2008)Impaired functional abilities, especially those associated with ambulation and standing balance, are common sequelae of brain tumors. A majority of research regarding the effectiveness of surgery in treating individuals ... -
Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
(University of Missouri--Columbia, 2005)In spinal cord-transected larval lamprey, descending brain neurons, most of which are reticulospinal (RS) neurons, regenerate their axons across a transection site and contribute to behavioral recovery. In the present ... -
Identifying the importance of phosphorylation of SNAP-25 at Ser187 in protein kinase C-mediated enhancement of exocytosis
(University of Missouri--Columbia, 2007)Protein Kinase C (PKC) activation has been shown to enhance exocytosis in various studies. However, the molecular mechanism for PKC to promote exocytosis is still elusive. A possible target of PKC is SNAP-25 (25 kDa ... -
Interaction between seratonin transporter genotype and prenatal stress on neurodevelopment with implications for autism spectrum disorder
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Prenatal stress has been shown to have a profound and lasting impact on brain development. Stress exposure during pregnancy has been implicated in ... -
Low-intensity blast-induced mild traumatic brain injury : linking blast physics to biological outcomes
(University of Missouri--Columbia, 2019)Blast-induced mild traumatic brain injury (mTBI) is of particular concern among military personnel due to exposure to blast energy during military training and combat. The impact of primary low-intensity blast (LIB) mediated ... -
Matrix metalloproteinase-9 : surrogate marker and therapeutic target against neurovascular impairment after cerebral ischemia
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Stroke ranks fourth among all causes of death, and acute ischemic stroke is the most common form. The neurovascular unit (NVU) describes a basic ... -
A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Stroke is the third leading cause of death in the United States and the major cause of adult disability. Ischemic stroke accounts for about 87 percent ... -
Network coherence in autism spectrum disorder : a multimodal neuroimaging study of functional connectivity and spectroscopy MRI
(University of Missouri--Columbia, 2015)The underlying neuropathology and effects on neuronal activity in individuals with ASD are still being elucidated; as well as their impact on intervention and treatment outcomes. Frontal, temporal, parietal and cerebellar ... -
Organization of brain and spinal cord locomotor networks in larval lamprey
(University of Missouri--Columbia, 2006)In vertebrates, brain locomotor command systems activate spinal central pattern generators (CPGs) to initiate locomotor behavior. The size and pharmacology of brain command systems are unknown, and the movements that result ... -
Real-time detection of dopamine -- aptamer interactions in a nanopore: a label-free toolkit for study of nucleic-acid-based molecular sensors.
(University of Missouri--Columbia, 2021)Understanding how small molecules regulate nucleic acid structures is important in both biomechanism elucidation and biotechnological applications. Through the conformational variation, native nucleic acid motifs can be ...