Browsing by Thesis Department "Neuroscience (MU)"
Now showing items 1-20 of 22
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Analysis of the Caenorhabditis elegans rpc-1 gene
(University of Missouri--Columbia, 2005)In eukaryotes, two large subunits form the core catalytic structure of RNA polymerase III (Pol III), which is conserved in other RNA polymerases, Pol I and Pol II. It has been found that Pol III activity is tightly associated ... -
Associations between psychophysiological, immune, endocrine, and serotonergic biomarkers of stress and gastrointestinal symptoms in autism spectrum disorder
(University of Missouri--Columbia, 2016)Autism spectrum disorder (ASD) is often accompanied by gastrointestinal (GI) disturbances, which also may impact behavior. Alterations in autonomic, endocrine, and immune system functioning are also frequently observed in ... -
CNS effects of blood-borne relaxin on the paraventricular nucleus of the hypothalamus
(University of Missouri--Columbia, 2013)Pregnancy is characterized by increased blood volume and baseline sympathetic nerve activity, and profound cardiovascular adaptations. Relaxin (RLX), an ovarian hormone which is elevated in pregnancy, activates the subfomical ... -
Dietary inflammatory index in patients with Alzheimer's dementia compared to controls
(University of Missouri--Columbia, 2018)Alzheimer's dementia (AD) is a chronic neurodegenerative disease causing progressive memory loss, cognitive decline across numerous domains, and, eventually, loss of daily living activities. Mild cognitive impairment (MCI) ... -
The effect of maternal genotype, prenatal stress, and perinatal diet in offspring behavior in an animal model of autism
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] While the etiology of autism spectrum disorders is unknown, it is thought that a combination of genetic and environmental factors contribute to the ... -
Effects of beta-adrenergic antagonism in autism spectrum disorder
(University of Missouri--Columbia, 2016)Effective treatments for individuals with autism spectrum disorder are lacking, especially when it comes to pharmacological intervention, which can be an important addition to behavioral therapy. Currently available agents ... -
Functional outcome and self-perceived overall health status following surgery to remove primary brain tumor
(University of Missouri--Columbia, 2008)Impaired functional abilities, especially those associated with ambulation and standing balance, are common sequelae of brain tumors. A majority of research regarding the effectiveness of surgery in treating individuals ... -
Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
(University of Missouri--Columbia, 2005)In spinal cord-transected larval lamprey, descending brain neurons, most of which are reticulospinal (RS) neurons, regenerate their axons across a transection site and contribute to behavioral recovery. In the present ... -
Identifying the importance of phosphorylation of SNAP-25 at Ser187 in protein kinase C-mediated enhancement of exocytosis
(University of Missouri--Columbia, 2007)Protein Kinase C (PKC) activation has been shown to enhance exocytosis in various studies. However, the molecular mechanism for PKC to promote exocytosis is still elusive. A possible target of PKC is SNAP-25 (25 kDa ... -
Interaction between seratonin transporter genotype and prenatal stress on neurodevelopment with implications for autism spectrum disorder
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Prenatal stress has been shown to have a profound and lasting impact on brain development. Stress exposure during pregnancy has been implicated in ... -
Low-intensity blast-induced mild traumatic brain injury : linking blast physics to biological outcomes
(University of Missouri--Columbia, 2019)Blast-induced mild traumatic brain injury (mTBI) is of particular concern among military personnel due to exposure to blast energy during military training and combat. The impact of primary low-intensity blast (LIB) mediated ... -
Matrix metalloproteinase-9 : surrogate marker and therapeutic target against neurovascular impairment after cerebral ischemia
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Stroke ranks fourth among all causes of death, and acute ischemic stroke is the most common form. The neurovascular unit (NVU) describes a basic ... -
A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Stroke is the third leading cause of death in the United States and the major cause of adult disability. Ischemic stroke accounts for about 87 percent ... -
Network coherence in autism spectrum disorder : a multimodal neuroimaging study of functional connectivity and spectroscopy MRI
(University of Missouri--Columbia, 2015)The underlying neuropathology and effects on neuronal activity in individuals with ASD are still being elucidated; as well as their impact on intervention and treatment outcomes. Frontal, temporal, parietal and cerebellar ... -
Organization of brain and spinal cord locomotor networks in larval lamprey
(University of Missouri--Columbia, 2006)In vertebrates, brain locomotor command systems activate spinal central pattern generators (CPGs) to initiate locomotor behavior. The size and pharmacology of brain command systems are unknown, and the movements that result ... -
Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system
(University of Missouri--Columbia, 2007)It is well known that ATP acts as a classic neurotransmitter in the central nervous system. It is stored in synaptic vesicles, released upon neuronal excitation, and activates both ion channel receptors (P2X) ... -
Role of P2Y₂ nucleotide receptors in reactive astrogliosis
(University of Missouri--Columbia, 2005)Astrocytes become activated in response to brain injury characterized by increased expression of GFAP and increased rates of cell migration and proliferation. Damage to brain cells causes the release of cytoplasmic ... -
The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
(University of Missouri--Columbia, 2016)Oxidative and nitrosative stress is known to play an important role in neurodegenerative and neuroinflammatory diseases, such as Alzheimer's disease, Parkinson's disease, ischemic[slash]hemorrhagic stroke, and traumatic ... -
The role of docosahexaenoic acid in stress reprogramming and behavior
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The role of DHA (Docosahexaenoic acid [22:6(n-3)]) is known to play an important role in complex behaviors such as learning and memory, anxiety and ... -
The role of the amygdala in palatability and homeostatic models of high-fat feeding
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Previous research has demonstrated a dissociation of certain neural mediators that contribute to the increased consumption of a high-fat diet following ...