Browsing by Thesis Department "Pharmacology (MU)"
Now showing items 1-11 of 11
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Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine
(University of Missouri--Columbia, 2007)Ischemia followed by reperfusion (I/R) is now well-recognized as one form of acute inflammation in which leukocytes play a key role. Preconditioning is a phenomenon through which antecedent exposure to a particular stimulus ... -
Design, synthesis, and evaluation of radiolabeled bombesin conjugates for the diagnosis of breast cancer
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Gastrin-releasing peptide (GRP) receptors are overexpressed on approximately two thirds (62-71%) of primary breast carcinomas and all (100%) of the ... -
Histone H3 phosphorylation and phosphoacetylation in the liver of rats treated in vivo with acute ethanol
(University of Missouri--Columbia, 2011)Epigenetic histone modification is emerging as a critical player in the cellular actions of ethanol. In this context, we administered ethanol intraperitoneally to rats, to mimic binge drinking in humans. A dose response ... -
The mechanism for paraquat toxicity involves oxidative stress and inflammation: a model for Parkinson's disease
(University of Missouri--Columbia, 2007)Parkinson's disease (PD) is a neurodegenerative disorder known to affect the dopaminergic neurons in the substantia nigra. Epidemiological studies have shown an increased risk of developing PD with exposure to paraquat. ... -
Membrane type 1 matrix metalloproteinase proteolytic activity in initial adhesive and invasive events of ovarian cancer metastasis
(University of Missouri--Columbia, 2014)Epithelial ovarian cancer (EOC) is one of the most common gynecologic malignancies, generally developing in women over the age of forty. When EOC are diagnosed prior to metastatic dissemination, the overall 5-year survival ... -
Microenvironmental regulation of ovarian cancer dissemination via activation of the Wnt signaling pathway
(University of Missouri--Columbia, 2012)Disseminating single cells and multicellular aggregates (MCAs) and experience compressive forces exerted upon them by ascites fluid and are exposed to lysophosphatidic acid, aberrantly adhesive mesothelium and a collagen-rich ... -
New gating states of Cystic Fibrosis transmembrane conductance regulator discovered via studying pathogenic mutations, pharmacological reagents and ATP analogs.
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cystic Fibrosis (CF), caused by the loss of function in the gene for the protein cystic fibrosis transmembrane conductance (CFTR), is one of the most ... -
P2Y�?? nucleotide receptor up-regulation and function in submandibular gland epithelium
(University of Missouri--Columbia, 2005)Sjögren's syndrome (SS) is an autoimmune disease that specifically targets exocrine glands, including salivary glands, and results in an impairment of secretory function. P2Y₂ nucleotide receptors for extracellular ATP ... -
The role of adipose tissue in the regulation of endothelial function in type 2 diabetes: mechanisms and therapeutic implications
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The prevalence of obesity and diabetes is rising dramatically worldwide. Increased adiposity is associated with elevated cardiovascular risk factors, ... -
Role of t-type ca 2+ channels in lymphatic pacemaking
(University of Missouri--Columbia, 2017)Lymphatic smooth muscle (LSM) contracts spontaneously, actively returning interstitial fluid through a network of lymphatic capillaries and collecting lymphatic vessels to the great veins. Dysfunctional lymphatic contractions ... -
The role of the age-dependent loss of alpha(E)-catenin in increased acute kidney injury
(University of Missouri--Columbia, 2015)The aging kidney undergoes structural and functional alterations which make it more susceptible to acute kidney injury (AKI). Previous studies in our laboratory have shown that the aging kidney has a marked loss of ...