Browsing by Thesis Department "Physiology (Medicine) (MU)"
Now showing items 1-20 of 44
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Alcohol induced histone acetylation mediated by histone acetyl transferase GCN5 in liver
(University of Missouri--Columbia, 2008)Although several mechanisms have identified for alcoholic liver disease, at present there are no precise mechanisms for liver injury. We have observed that surrogate alcohols increases histone H3 acetylation selectively ... -
Attenuation of rapid onset vasodilation with advanced age : roles of adrenergic and endothelial signaling
(University of Missouri--Columbia, 2016)Rapid onset vasodilation (ROV) occurs immediately in response to skeletal muscle contraction and initiates a prompt increase in blood flow and oxygen delivery that facilitate the transition to exercise. Muscle blood flow ... -
Caveolin-1 A scaffold for microcompartmental organization of membrane-associated glycolysis
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The role of membrane caveolae in the compartmentation of membrane glycolytic metabolism indicates a pivotal role of caveolin in the localization of ... -
Chlorinated lipid induce inflammatory responses in the microcirculation
(University of Missouri--Columbia, 2017)Previous studies from our research group have shown that chlorinated lipid, generated from the neutrophil-myeloperoxidase (MPO) system, are elevated in a rat sepsis model as well as in plasma of septic patients. Other work ... -
Collecting lymphatic vessel permeability to albumin and its modification by natriuretic peptides
(University of Missouri--Columbia, 2010)Microvascular exchange is the process whereby the blood provides the tissues of the body nutrients for cellular metabolism, macromolecules essential for fighting infection, and waste removal. However, these constituents ... -
Contribution of AT1R mechanoactivation to the arterial myogenic response and its regulation by RGS5 protein in skeletal muscle arterioles
(University of Missouri--Columbia, 2015)Although intracellular mechanisms underlying the arteriolar myogenic response have been well-defined, the mechanotransduction events transducing the mechanical stimulus remain unclear. Recently, ligand-independent activation ... -
The contribution of titin to striated muscle shortening
(University of Missouri--Columbia, 2008)Striated muscle shortens under various loads (i.e., performs work), which allows movement of the skeleton and pumping of blood throughout the circulatory system. The amount of work that a muscle can do is determined by the ... -
The control of blood flow in skeletal muscle arterioles
(University of Missouri--Columbia, 2010)Skeletal muscle arterioles dilate in response to application of acetylcholine (ACh), eliciting a conducted vasodilation (CVD) that travels along unbranched segments without decrement. CVD is known to entail cell-to-cell ... -
The effect of troponin I phosphorylation on the steepness of the Frank-Starling relationship
(University of Missouri--Columbia, 2013)Heart failure begins with a reduction in the contractile strength of the cardiac myocytes (systolic dysfunction.) Cardiac myofibrils compensate via sympathetic activation to maintain adequate cardiac output. Beta-adrenergic ... -
Effects of ischemic metabolites and chronic exercise on cardiac myocyte function
(University of Missouri--Columbia, 2005)During times of low blood flow (ischemia), concentrations of wastes increase in tissues, which can lead to decreased striated muscle contractile function. Acute cardiac contractile dysfunction during ischemia is likely ... -
The effects of physical activity on adipose tissue metabolism and DNA methylation
(University of Missouri--Columbia, 2009)The increased prevalence of obesity and diabetes threatens both the real and economic health of Western counties. There were two major goals of this dissertation, 1) to determine if in response to inactivity and hyperphagia ... -
The effects of sex and ovarian hormones on arterial baroreflex control of blood pressure in humans
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The arterial baroreceptors are responsible for mediating rapid reflex adjustments to acute cardiovascular stressors via modulating autonomic nervous ... -
Efficacy of TNF inhibitor treatment in a model of heart failure and resulting cachexia
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The aim this dissertation was to explore the efficacy of tumor necrosis factor (TNF) inhibitors in attenuating increases in both anorexia and the ... -
Endothelial phenotype differs by both sex and vessel function
(University of Missouri--Columbia, 2017)Endothelial cells (the cells that line our blood vessels) were once thought to be an inert cellophane-like wrapper separating flowing blood from tissue. However, as our understanding of the human body has progressed, we ... -
Expression of adiponectin receptors by vascular smooth muscle cells
(University of Missouri--Columbia, 2009)Adiponectin (APN) is a 30-kDA insulin-sensitizing protein with strong effects on the vasculature. It binds three receptors: AdipoR1, AdipoR2, and T-cadherin. APN and AdipoRs are well-studied in the vascular endothelium, ... -
Expression of IGF2R, IGF2, TGF, and uPAR in a rat model of obesity
(University of Missouri--Columbia, 2017)We tested the hypothesis that induction of obesity in lean Long Evans Tokushima Otsuka (LETO) and obesity-prone Otsuka Long Evans Tokushima Fatty (OLETF) would cause the insulin growth factor 2 receptor (IGF2R) and factors ... -
Functional and pharmacological importance of the composite ATP binding site 1 in CFTR chloride channels
(University of Missouri--Columbia, 2010)The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel whose defects cause the deadly genetic disease cystic fibrosis (CF). Like other ATP binding cassette (ABC) proteins, CFTR encompasses ... -
Functional differences between pericytes and vascular smooth muscle cells during vascular morphogenesis
(University of Missouri--Columbia, 2011)During vascular morphogenic events, mural cells are recruited to developing endothelial tubes to aid in stabilization and maturation of the new vessels. There are two known types of mural cells, pericytes and vascular ... -
Hypochlorous acid stimulates heme oxygenase-1 gene expression in human endothelial cells
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] In the present study, we tested the hypothesis that Hypochlorous acid (HOCl) regulates the expression of the cytoprotective protein heme oxygenase-1 ... -
Lipotoxicity in smooth muscle
(University of Missouri--Columbia, 2006)Atherosclerosis and bladder dysfunction can both result from the high lipid levels that occur with obesity and diabetes and can cause cell dysfunction and death, termed lipotoxicity, in various cell types. However, ...