Browsing by Thesis Department "Veterinary biomedical sciences (MU)"
Now showing items 1-20 of 78
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6-Thioguanine and zebularine globally demethylate a canine lyphoma cell line
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Epigenetic modifications of chromatin, including methylation, histone modifications, and protein chaperoning, play a significant role in the biology ... -
Acute and chronic adaptations to intermittent pnemuatic [sic] leg compressions
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Few therapies exist that improve functional capacity and quality of life of patients with peripheral arterial disease (PAD). Despite the growing ... -
Analysis of coffin and shoulder joint lameness with an inertial sensor-based system : impact versus pushoff
(University of Missouri--Columbia, 2012)Reason for performing the study: An inertial sensor-based system (Lameness Locator[copyright] [LL]) can help veterinarians detect mild lameness. It would be beneficial if this tool could also be used to distinguish lamenesses ... -
The antiendotoxin effects of polymyxin B in a feline model of endotoxemia
(University of Missouri--Columbia, 2010)Introduction: Directed, effective therapies for feline sepsis are needed to reduce the high morbidity and mortality associated with this disease. Materials and Methods: We investigated the anti-endotoxin effects of PMB in ... -
Apigenin : chemopreventive and chemotherapeutic potential for progestin-dependent breast cancer
(University of Missouri--Columbia, 2012)Use of estrogen-progestin hormone replacement therapy (HRT) has been linked to increased risk of breast cancer, an effect that has been attributed to the progestin component. Commonly available antiprogestins are associated ... -
Canine pharmacodynamic assays: applications in immune-mediated disease
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Immune-mediated diseases are commonly diagnosed in veterinary medicine and a high rate of mortality, expense and complications of immunosuppressive ... -
Cardiorespiratory fitness through the early lifecourse and attempts to modulate its initial decline
(University of Missouri--Columbia, 2015)There has never been an outcome measure for human health more important than VO2peak, yet we know nothing about the molecular triggers for its decline with aging. Peak aerobic capacity (VO2peak) is a strong predictor of ... -
Characterization of the alignment of the canine pelvic limb
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Angular limb deformities are common place in the canine. Until recently, repair of deformities was based upon crude radiographic measures of bone ... -
Characterization of the humoral immune response to a commercial staphylococcus aureus mastitis vaccine
(University of Missouri--Columbia, 2006)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The objective of this thesis was to test the hypothesis that a commercial vaccine for bovine S. aureus mastitis fails to induce a humoral immune response ... -
Cholesterol synthesis inhibitors prevent growth and metastasis of breast cancer cells
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Clinical trials and studies show that post-menopausal women undergoing hormone replacement therapy containing a combination of estrogen and progestin ... -
Clinical and treatment perspectives for heart failure with preserved ejection fraction /
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Heart failure with preserved ejection fraction (HFpEF) currently represents half of the ~6 million heart failure patients in the United States, and is ... -
Comparative imaging of canine shoulder osteochondrosis lesions
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Over the last several years, papers have been published describing imaging techniques for the canine shoulder joint using both ultrasound and magnetic ... -
Comparison of an inertial sensor based system of lameness quantification to subjective lameness evaluation
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Recently developed wireless inertial sensor systems provide a means to objectively detect lameness as a horse is trotted over natural footing. The ... -
Comparison of left 4th and 5th intercostal space thoracotomy for open-chest cardiopulmonary resuscitation in dogs
(University of Missouri--Columbia, 2018)Open-chest cardiopulmonary resuscitation (OC-CPR) is indicated in certain cardiopulmonary arrest situations such as thoracic trauma. Laboratory research and clinical studies in human medicine have established the superiority ... -
Comprehensive characterization of canine meniscal pathology
(University of Missouri--Columbia, 2010)Meniscal injury is one of the most common causes of pain and dysfunction in the human knee and canine stifle joint. In the canine patient, meniscal injury is usually secondary to cranial cruciate ligament rupture, and the ... -
The cystic fibrosis transmembrane conductance regulator and acid-base transporters of the murine duodenum
(University of Missouri--Columbia, 2006)The alkaline mucus barrier of the duodenum plays an important role in protecting the epithelium from acidic chyme entering from the stomach. Active HCO₃⁻ secretion involves the apical membrane activities of the cystic ... -
Cytauxzoon felis : an emerging feline pathogen and potential therapy
(University of Missouri--Columbia, 2011)Cytauxzoon felis is a pathogenic hemoprotozoal parasite of Felidae. We were able to document, via both piroplasm detection and PCR analysis, a chronic carrier state in naturally infected captive bred tigers as well as ... -
Development of a motor unit number estimation technique in normal dogs : a potential biomarker for canine degenerative myelopathy
(University of Missouri--Columbia, 2011)Motor unit number estimation (MUNE) is an electrophysiologic technique for quantifying the lower motor neuron (LMN) system. MUNE has proven useful in evaluating and monitoring neurodegenerative diseases such as amyotrophic ... -
Double pelvic osteotomy for the treatment of hip dysplasia in dogs
(University of Missouri--Columbia, 2011)Canine hip dysplasia (CHD) is the most common developmental orthopedic disease of dogs. Triple pelvic osteotomy (TPO) is a surgery that can be performed at 5 months of age, prior to the development of osteoarthritis. ... -
The effect of free fatty acids on endothelial cells
(University of Missouri--Columbia, 2005)The purpose of this thesis was to determine if specific components of oxidized low density lipoprotein (OxLDL) molecules e.g. oxidized polyunsaturated fatty acids (PUFAs), or saturated free fatty acids (FFA) are alone ...