Browsing by Thesis Advisor "Booth, Frank W."
Now showing items 1-15 of 15
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Cardiorespiratory fitness through the early lifecourse and attempts to modulate its initial decline
(University of Missouri--Columbia, 2015)There has never been an outcome measure for human health more important than VO2peak, yet we know nothing about the molecular triggers for its decline with aging. Peak aerobic capacity (VO2peak) is a strong predictor of ... -
The effects of physical activity on adipose tissue metabolism and DNA methylation
(University of Missouri--Columbia, 2009)The increased prevalence of obesity and diabetes threatens both the real and economic health of Western counties. There were two major goals of this dissertation, 1) to determine if in response to inactivity and hyperphagia ... -
Effects of voluntary running on brain mitochondrial biogenesis in rats selectively bred to run high and low nightly distances
(University of Missouri--Columbia, 2015)It is known that brain mitochondrial dysfunction is strongly associated with the advent of neurodegenerative diseases and that exercise is an important non-pharmaceutical method of maintaining brain mitochondrial health. ... -
Efficacy of TNF inhibitor treatment in a model of heart failure and resulting cachexia
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The aim this dissertation was to explore the efficacy of tumor necrosis factor (TNF) inhibitors in attenuating increases in both anorexia and the ... -
Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 8/1/2024] Physical activity has played an essential role in the evolution of humans and the development of the human brain. Therefore, it comes as no surprise that the modern-day pandemic levels of sedentarism ... -
Examination of nucleus accumbens mechanisms underlying the motivation for physical activity
(University of Missouri--Columbia, 2017)Physical inactivity, a primary contributor to numerous diseases including obesity, type 2 diabetes, depression, and dementia, has reached pandemic levels worldwide. Alarmingly, the percentage of individuals engaging in ... -
Fgf2-stimulated proliferation is lower in muscle precursor cells from old rats
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In aged skeletal muscle, impairments in the regrowth and regeneration may be explained by a decreased responsiveness of muscle precursor cells (MPCs), ... -
Maladaptation of cardiac and skeletal muscle in chronic disease : effects of exercise
(University of Missouri--Columbia, 2007)The human genome is adapted for daily physical activity (85). Thus, a sedentary lifestyle is capable of promoting detrimental consequences to human health. The linkage between lack of sufficient physical activity and the ... -
Mechanisms regulating skeletal muscle satellite cell cycle progression
(University of Missouri--Columbia, 2006)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Skeletal muscle fibers are multinucleated with each myonucleus capable of governing a finite cytoplasmic volume. In healthy skeletal muscle, myonuclear ... -
Metabolic responses to a westernized diet administered to rats selectively bred for high and low amounts of voluntary exercise
(University of Missouri--Columbia, 2015)Introduction: The purpose of my study was to determine if rats with varying levels of inherent motivation to voluntarily run in wheels, when given no access to voluntary running wheels, would retain any protective affects ... -
The molecules that move us : evaluating potential genetic and molecular determinants of physical activity motivation
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Physical activity is at the basis of human history. The fact that we occupy every continent, were built for long distance travel, and that we find ... -
Physiological responses of adipose tissue to different models of physical activity and inactivity
(University of Missouri--Columbia, 2013)Childhood is a critical time of growth, and decisions made during this time lead to positive and negative health consequences, specifically pertaining to adiposity. There is convincing evidence that children who are ... -
Rats selectively-bred for low and high voluntary running: co-selected traits and the effects of voluntary running on the dentate gyrus transcriptome
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Booth lab at the University of Missouri has selectively-bred Wistar rats for low (LVR) and high (HVR) voluntary running behavior as a model for ... -
The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)Mild cognitive impairment (MCI) was defined as a boundary area between cognitive function of natural aging and dementia. Early studies have suggested that MCI could be a therapeutic window for prevention of dementia, given ... -
The role of resistance exercise training & IGF-1 signaling in the amelioration of mild cognitive impairment in female Wistar rats
(University of Missouri--Columbia, 2021)Mild cognitive impairment increases risk for dementia. One therapeutic intervention that is reported to ameliorate cognition in patients with mild cognitive impairment is resistance exercise. However, the underlying ...