Browsing by Thesis Advisor "Buszek, Keith R."
Now showing items 1-9 of 9
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Ab Initio Density Functional Theory Charge Distributions of Vinyltrimethylphosphonium, Vinylphosphorinium, and Vinyldiphosphonium Tetrafluoroborate Salts with Mechanistic Studies of Phospha-Michael Additions to Activated Acetylenes
(2022)While vinylammonium and vinylpyridinium tetrafluoroborate salts have previously been well investigated by the Buszek research group in their applications to Diels-Alder and other reactions, very little is known about their ... -
Ab Initio Density Functional Theory Optimized Geometries of Vinyl Trialkylammonium, Vinylpyridinium and Vinyldiazonium Tetrafluoroborate Salts with Natural Bond Orbital Charge Distributions in the Gas Phase
(2022)N-Vinyltrialkylammonium and N-vinylimmonium tetrafluoroborate salts are novel classes of compounds discovered by Buszek and Jung. They were originally used as dienophiles and as ß-dialkylamino equivalents in Diels-Alder ... -
Design, Preparation, And Applications Of Novel N-Vinyliminium Salts in Organic Synthesis. Design and Synthesis of Tau Aggregate-specific Fluorescent Probes for Postmortem Imaging of Brains with Tauopathies
(2023)PART I Efforts to optimize the electrophilic coupling partners for the Suzuki reaction by electronically and sterically tuning the pyridinium moiety are described. Both reaction temperature and catalyst loading have been ... -
I. Structure-Activity Relationship Studies of 6,7-Annulated-5-Substituted Libraries. II. Current Efforts Towards The Synthesis of 4-Azaindole Aryne Precursors
(2015)A contemporary and highly valued method for drug discovery involves the synthesis of libraries or collections of novel compounds from interesting molecular scaffolds, often inspired by biologically active, naturally occuring ... -
Indole Arynes in organic synthesis : discovery and applications for the total synthesis of complex natural products
(University of Missouri -- Kansas City, 2011-05-03)Arynes and heteroarynes are very important and useful reactive intermediates with many applications in organic synthesis, including natural products total synthesis. Although benzyne, the parent and most famous aryne, has ... -
Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
(2014)Dissertation under the direction of Keith R. Buszek, Ph.D., Professor of Chemistry, University of Missouri-Kansas City. Heterocyclic chemistry is one of the most valuable sources of novel compounds with diverse biological ... -
Recent Advances in Hetaryne Chemistry. Efforts Toward the Development of a Single Platform for the Generation of 4,5-, 5,6-, and 6,7-Indole Arynes
(University of Missouri--Kansas City, 2017)In the beginning of 2007, indole arynes and their cycloaddition chemistry were discovered by Buszek laboratories. Since then, indole arynes and their cycloaddition chemistry have demonstrated their value in the ... -
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ... -
Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
(2013)Total synthesis of benzannulated indole alkaloid natural products (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B via intermolecular indole aryne cycloaddition are described. The 5,6,7-tribromoindole was ...