Browsing by Thesis Advisor "Caldwell, Charles W., M.D."
Now showing items 1-5 of 5
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Affects of the inhibition of microRNA regulatory machinery in lymphoma cells [abstract]
(2010-11)MicroRNAs influence many processes such as development, cell proliferation and differentiation and cell death. MicroRNAs are intergrated into a complex called RISC with Argonatue proteins to target mRNAs. Recent studies ... -
Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia
(University of Missouri--Columbia, 2011)B-cell Chronic Lymphocytic Leukemia (B-CLL) is the most common hematological malignancy in United States[1], characterized by CD5+ B-lymphocytes in peripheral blood. Deregulation of the Notch signaling pathway has been ... -
Large scale CpG island methylation profiling of small B cell lymphoma
(University of Missouri--Columbia, 2008)DNA methylation plays a significant role in cellular differentiation and biologic activity through silencing of gene expression and also appears to be a factor in the progression of different types of cancer, including ... -
The role of DNA methylation on gene expression in actue lymphoblastic leukemia
(2010-11)Epigenetic modification of the genome has more influence on gene expression than DNA sequence alone. DNA hypermethylation and deacetylation of histone complexes has been shown to down regulate expression of associated ... -
RT-PCR on magnetically sorted B-cell subsets from pediatric bone marrow [abstract]
(2010-11)Acute lymphoblastic leukemia (ALL) is characterized by the uncontrolled proliferation of lymphoblasts which have been arrested in an early stage of B-cell differentiation. A key obstacle in identifying biomarkers of malignant ...