Browsing by Thesis Advisor "Dobens, Leonard L."
Now showing items 1-5 of 5
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A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target
(University of Missouri -- Kansas City, 2017)In this dissertation, I used the Drosophila wing as a model tissue for a genetic screen to identify novel targets of Tribbles. Drosophila Tribbles is the founding member of a family of pseudokinases conserved between ... -
Identification of motifs in the tribbles kinase required for substrate interactions
(2013)The gene tribbles encodes an atypical kinase that is evolutionarily conserved with important roles in regulation of cell signaling. In Drosophila melanogaster Tribbles (Trbl) directs the proteasomal degradation of the ... -
Investigation of functional domains of drosophilia tribbles protein in the insulin signaling pathway
(2020)In this dissertation, I examined the function of the Drosophila melanogaster protein Tribbles (Trbl) within the insulin/insulin-like signaling (IIS) pathway. Trbl was initially discovered as a regulator of mitosis during ... -
The Roles of the Drosophila Protein Tribbles in Oogenesis and Insulin Signaling Pathway
(2015-06-02)In this dissertation, I examined the molecular mechanism of function of the Drosophila melanogaster protein Tribbles (Trbl) during oogenesis and larval development. Trbl is the founding member of an evolutionarily conserved ... -
Structure-Function Analysis of the Tribbles Pseudokinase
(2020)Members of the Tribbles (Trb) family of pseudokinases have roles in development, cell cycle control, insulin signaling, and the immune response and have been linked to many human diseases. The structure of Drosophila ...