Browsing by Thesis Department "Medical Pharmacology and Physiology (MU)"
Now showing items 1-20 of 70
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Alcohol induced histone acetylation mediated by histone acetyl transferase GCN5 in liver
(University of Missouri--Columbia, 2008)Although several mechanisms have identified for alcoholic liver disease, at present there are no precise mechanisms for liver injury. We have observed that surrogate alcohols increases histone H3 acetylation selectively ... -
Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine
(University of Missouri--Columbia, 2007)Ischemia followed by reperfusion (I/R) is now well-recognized as one form of acute inflammation in which leukocytes play a key role. Preconditioning is a phenomenon through which antecedent exposure to a particular stimulus ... -
Attenuation of rapid onset vasodilation with advanced age : roles of adrenergic and endothelial signaling
(University of Missouri--Columbia, 2016)Rapid onset vasodilation (ROV) occurs immediately in response to skeletal muscle contraction and initiates a prompt increase in blood flow and oxygen delivery that facilitate the transition to exercise. Muscle blood flow ... -
Cardiomyocyte calcium and stress-induced ventricular arrhythmia
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and is caused by mutations in the dystrophin gene. Subclinical signs of cardiac disease present early and usually progress ... -
Caveolin-1 A scaffold for microcompartmental organization of membrane-associated glycolysis
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The role of membrane caveolae in the compartmentation of membrane glycolytic metabolism indicates a pivotal role of caveolin in the localization of ... -
CFTR gating mechanism : the role of dimerization of nucleotide binding domains
(University of Missouri--Columbia, 2009)The chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR) has two membrane spanning domains (MSD), forming the channel pore, and two nucleotide binding domains (NBD), controlling the channel gating ... -
Chlorinated lipid induce inflammatory responses in the microcirculation
(University of Missouri--Columbia, 2017)Previous studies from our research group have shown that chlorinated lipid, generated from the neutrophil-myeloperoxidase (MPO) system, are elevated in a rat sepsis model as well as in plasma of septic patients. Other work ... -
Collecting lymphatic vessel permeability to albumin and its modification by natriuretic peptides
(University of Missouri--Columbia, 2010)Microvascular exchange is the process whereby the blood provides the tissues of the body nutrients for cellular metabolism, macromolecules essential for fighting infection, and waste removal. However, these constituents ... -
Comparing calcium handling in right and left ventricle cardiomyocytes in type III pulmonary hypertension
(University of Missouri--Columbia, 2024)[EMBARGOED UNTIL 05/01/2025] Type III pulmonary hypertension (PH) is characterized by pulmonary fibrosis, leading to elevated pressure in the pulmonary arteries and hypertrophy of the right ventricle (RV). Yet, effects of ... -
Contribution of AT1R mechanoactivation to the arterial myogenic response and its regulation by RGS5 protein in skeletal muscle arterioles
(University of Missouri--Columbia, 2015)Although intracellular mechanisms underlying the arteriolar myogenic response have been well-defined, the mechanotransduction events transducing the mechanical stimulus remain unclear. Recently, ligand-independent activation ... -
The contribution of titin to striated muscle shortening
(University of Missouri--Columbia, 2008)Striated muscle shortens under various loads (i.e., performs work), which allows movement of the skeleton and pumping of blood throughout the circulatory system. The amount of work that a muscle can do is determined by the ... -
The control of blood flow in skeletal muscle arterioles
(University of Missouri--Columbia, 2010)Skeletal muscle arterioles dilate in response to application of acetylcholine (ACh), eliciting a conducted vasodilation (CVD) that travels along unbranched segments without decrement. CVD is known to entail cell-to-cell ... -
Design, synthesis, and evaluation of radiolabeled bombesin conjugates for the diagnosis of breast cancer
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Gastrin-releasing peptide (GRP) receptors are overexpressed on approximately two thirds (62-71%) of primary breast carcinomas and all (100%) of the ... -
Dystrophic cardiomyopathy: the role of myofilaments
(University of Missouri--Columbia, 2022)Dystrophic cardiomyopathy is the consequence of diseases that affect the protein dystrophin. Dystrophin forms part of the dystrophin glycoprotein complex and is postulated to act as a membrane stabilizer, protecting the ... -
EC-SGK1 and EnNaC mediate vascular stiffening
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Vascular stiffening is an independent predictor of cardiovascular diseases, the leading cause of death worldwide. High dietary salt intake has been shown to increase vascular stiffness in humans, ... -
The effect of lead on Renal cell carcinoma progression
(University of Missouri--Columbia, 2023)Renal cell carcinoma (RCC) incidence has been steadily increasing over the past few decades, and has become the ninth most common cancer in the United States. It has the highest mortality rate of the genitourinary cancers, ... -
The effect of troponin I phosphorylation on the steepness of the Frank-Starling relationship
(University of Missouri--Columbia, 2013)Heart failure begins with a reduction in the contractile strength of the cardiac myocytes (systolic dysfunction.) Cardiac myofibrils compensate via sympathetic activation to maintain adequate cardiac output. Beta-adrenergic ... -
Effects of ischemic metabolites and chronic exercise on cardiac myocyte function
(University of Missouri--Columbia, 2005)During times of low blood flow (ischemia), concentrations of wastes increase in tissues, which can lead to decreased striated muscle contractile function. Acute cardiac contractile dysfunction during ischemia is likely ... -
Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
(University of Missouri--Columbia, 2022)Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy that is caused by a mutation in the dystrophin gene which is located on the X chromosome. DMD affect 1 in 3,600 males at birth. Due to recent ... -
The effects of physical activity on adipose tissue metabolism and DNA methylation
(University of Missouri--Columbia, 2009)The increased prevalence of obesity and diabetes threatens both the real and economic health of Western counties. There were two major goals of this dissertation, 1) to determine if in response to inactivity and hyperphagia ...