Browsing by Thesis Advisor "Sun, Grace Y."
Now showing items 1-7 of 7
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Activation of astrocytes: involvement of NADPH oxidase and cytosolic phospholipase A2
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Reactive oxygen species (ROS) are produced in cells by enzymic and non-enzymic mechanisms and play important roles in the pathogenesis of neurodegenerative ... -
Amyloid beta induces cPLA2 activation by an NADPH oxidase-dependent mechanism in neurons
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Alzheimer's disease (AD) is a neurodegenerative disorder affecting more than 20 million people worldwide. An increase in production of amyloid beta ... -
Amyloid-beta toxicity in neurons and potential botanical compounds for prevention of Alzheimer's disease
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Alzheimer's disease (AD) is characterized by a progressive decline in memory and cognitive function together with increased oxidative stress in the ... -
Green tea epigallocatechin-3-gallate (EGCG) inhibits cytokine-induced nitric oxide and secretory phospholipase A2-IIA in glial cells [abstract]
(2010)Glial cells, including astrocytes and microglial cells, are activated in response to injury and neurodegenerative diseases. In culture studies, astrocytes and microglial cells are capable of responding to proinflammatory ... -
The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
(University of Missouri--Columbia, 2016)Oxidative and nitrosative stress is known to play an important role in neurodegenerative and neuroinflammatory diseases, such as Alzheimer's disease, Parkinson's disease, ischemic[slash]hemorrhagic stroke, and traumatic ... -
Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes
(University of Missouri--Columbia, 2009)Alzheimer's disease (AD) is a progressive, fatal neurodegenerative disease marked with dementia. Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to have a role in the pathogenesis of multiple ... -
Tnf[alpha] alters occludin and endothelial cell barrier function : role of p38MAPK
(University of Missouri--Columbia, 2016)Occludin is one of the key tight junction (TJ) proteins in endothelial cells and it plays an important role in modulating blood brain barrier (BBB) function. This protein (65kDa) has been shown to engage in many signaling ...