Browsing by Thesis Department "Veterinary pathobiology (MU)"
Now showing items 1-20 of 71
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Adding pieces to the monocytic ehrlichiosis puzzle : treatment, etiology and protection with a canine model
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Infections with Ehrlichia canis cause Canine Monocytic Ehrlichiosis (CME), a disease which causes morbidity and mortality of dogs worldwide. Currently, ... -
Advances in the fundamental cryobiology of mammalian oocytes
(University of Missouri--Columbia, 2007)Having effective means to cryopreserve mammalian oocytes could increase the efficiency of managing populations of laboratory animals, increase the effectiveness of breeding programs for livestock, and improve the means by ... -
Amino-terminal sequences of the bacillus anthracis exosporium proteins BCLA and BCLB important for localization and attachment to the spore surface
(University of Missouri--Columbia, 2008)The exosporium is the outermost layer of the Bacillus anthracis spore. The predominant protein on the exosporium surface is BclA, a collagen-like glycoprotein. BclA is incorporated on the spore surface late in the B. ... -
Arsenic speciation of swine urine for possible use in human exposure assessments
(University of Missouri--Columbia, 2013)Commonly found arsenic species in human urine are AsIII (arsenite), AsV (arsenate), MMA (monomethyl arsenic acid), DMA (dimethylarsinic acid) and AB (arsenobetaine). Evidence has shown that these species vary in toxicity ... -
Assessment of biomarker production by osteoarthritic osteochondral tissues and correlation to the biomechanical, biochemical, and histological properties
(University of Missouri--Columbia, 2016)Osteoarthritis (OA) is the most prevalent form of arthritis and is a significant cause of pain and disability worldwide. Treatment options available are only capable of controlling symptoms until progression to end-stage ... -
Autologous bone marrow-derived mesenchymal stem cell transplantation as a therapy for neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2007)The Neuronal Ceroid Lipofuscinoses (NCLs) are a group of rare genetic diseases characterized by neurodegeneration and accumulation of autofluorescent lysosomal storage bodies in numerous cell types. There are currently no ... -
Biochemical characteristics of different subtypes of human immunodeficiency virus type 1 reverse transcriptase and its interactions with the host factor : apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Human immunodeficiency virus (HIV) is divided into type 1 (HIV-1) and type 2 (HIV-2). Whereas HIV-2 accounts for 5% of global infections, HIV-1 is ... -
Biodistribution of lead, arsenic, and gold nanoparticles following respiratory, oral and IV exposure of rats and swine
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The presence of arsenic and lead in the environment above the naturally occurring levels can have detrimental health effects on people living in these ... -
Cellular and molecular mechanisms underlying immune tolerance against type 1 diabetes /
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Type 1 diabetes (T1D), also known as insulin-dependent diabetes mellitus, is a chronic autoimmune disease caused by the destruction of insulin-producing ... -
Characterization of interactions involving the polycystic kidney disease-causing proteins: SamCystin and Bicc1
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rodent models, including the Han:SPRD-Cy rat and the jcpk mouse, have been useful for identifying and characterizing genes that cause Polycystic Kidney ... -
Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteogenesis imperfecta (OI) is a heritable connective tissue disorder hallmarked by bone fragility resulting primarily from mutations in the ... -
Characterization of the pigmentation locus in Yersinia pestis pathogenesis of pneumonic plague
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ... -
Characterization of the sporozoite and eythrocytic stages (SES) protein
(University of Missouri--Columbia, 2007)The Plasmodium sporozoite is infective for mosquito salivary glands and vertebrate host tissues. Although it is a key developmental stage of the malaria parasite, relatively few sporozoite surface or secreted proteins have ... -
Characterizing the progression of disease associated with human meniscal pathology
(University of Missouri--Columbia, 2013)Meniscal fibrocartilaginous structures are subject to numerous stresses when performing its necessary functions to maintain intra-articular homeostasis. Pathological events causing a loss of tissue integrity will result ... -
Comparative fundamental cryobiology of mouse embryonic stem cells
(University of Missouri--Columbia, 2009)Mouse embryonic stem cell (mESC) lines are central to projects such as the Knock-Out Mouse Project, which seek to create thousands of mutant mouse strains using mESCs for the production of human disease models. The ability ... -
Complex microbiota targeted rederivation (CMTR) as an alternative method to study effect of gut microbiota on host physiology /
(University of Missouri--Columbia, 2016)Rodent models are invaluable tools to study the effects of differing gut microbiota (GM) on health and disease. Our laboratory has demonstrated that mouse GM profiles vary among animal vendors suggesting that subtle ... -
Cruciate ligament pathogenesis and its role in the initiation and progression of osteoarthritis
(University of Missouri--Columbia, 2008)The pathogenesis of cruciate ligament disease and how it may be linked to the initiation and progression of osteoarthritis were investigated using in vitro and in vivo models. Normal and diseased tissues were initially ... -
Decreasing perinatal bovine leukosis virus infection in calves
(University of Missouri--Columbia, 2006)Bovine leukosis virus (BLV) is an oncogenic retrovirus of cattle that causes lymphosarcoma in a proportion of infected individuals. Currently the United States estimates are that 44% of dairy cattle and 10% of beef cattle ... -
Defining the therapeutic window in spinal muscular atrophy :
(University of Missouri--Columbia, 2013)Spinal muscular atrophy (SMA) is caused by the loss of a single gene, survival motor neuron-1 (SMN1), which results in the rapid deterioration of motor neuron integrity and function, most often leading to infantile death. ... -
Development and characterization of a novel meniscal extracellular matrix-derived scaffold /
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Musculoskeletal injuries are a common and significant problem in orthopaedic practice. Despite advances in orthopaedic surgery, effective treatments ...